{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Caro I"],"funding":["NCATS NIH HHS","U.S. Department of Health Human Services | NIH | Center for Information Technology (Center for Information Technology, National Institutes of Health)","NIDDK NIH HHS","NIA NIH HHS","NHLBI NIH HHS","NINDS NIH HHS","Agence Nationale de la Recherche (French National Research Agency)"],"pagination":["2514-2531"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12705447"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["5(12)"],"pubmed_abstract":["Cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia with no specific treatment, of which molecular mechanisms remain poorly understood. To identify potential biomarkers and therapeutic targets, we applied Mendelian randomization to examine over 2,500 proteins measured in plasma and, uniquely, cerebrospinal fluid, in relation to magnetic resonance imaging (MRI) markers of cSVD in more than 40,000 individuals. Here we show that 49 proteins are associated with MRI markers of cSVD, most prominently in cerebrospinal fluid. We highlight associations that are consistent across platforms and ancestries, and supported by complementary observational analyses, and we explore differences between fluids. The proteins are enriched in pathways related to the extracellular matri"],"journal":["Nature aging"],"pubmed_title":["Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease."],"pmcid":["PMC12705447"],"funding_grant_id":["N01 HC085083","N01 HC085082","N01 HC085081","N01 HC085086","UL1 TR001881","U01 HL080295","RF1 AG059421","N01 HC085080","ANR-18-RHUS-0002, ANR-10-COHO-05","R01 AG023629","R01 AG044546","RF1 AG063507","HHSN268201200036C","P30 AG066444","R01 NS129032","U01 AG058922","R00 AG062723","R01 HL087652","P30 AG066546","RF1 AG074007","R01 HL120393","75N92021D00006","HHSN268200800007C","RF1 AG058501","N01 HC055222","RF1 AG053303","R01 HL172803","HHSN268201800001C","R01NS129032","R01 HL103612","P01 AG026276","P30 DK063491","N01 HC085079","R01 HL105756","P01 AG003991","U01 HL130114"],"pubmed_authors":["Psaty BM","Rotter JI","Koido M","Kawaguchi S","Sun N","Munter M","Matsuda F","Tzourio C","Puerta R","Matsuda K","Jandaghi P","Heiman M","Kamatani Y","Yang C","Debette S","Astafeva I","Cruchaga C","He Y","Kanai A","Boada M","Ahmadi M","Tsuchida A","Fornage M","Tregouet DA","Caro I","Joliot M","Couffinhal T","Marquie M","Sargurupremraj M","Oda Y","Suzuki Y","Ibanez L","De Jager PL","Duperron MG","Fujita M","Timsina J","Garcia-Gonzalez P","Roshchupkin G","Wardlaw JM","Western D","Kellis M","Longstreth WT","Seshadri S","Adams H","Bis JC","Okada Y","Mishra A","Namba S","Le Grand Q","Pytel V","Launer LJ","D'Aoust T","Ruiz A","Matthews PM","Auld D","Cano A","Lathrop M"],"additional_accession":[]},"is_claimable":false,"name":"Proteogenomics in cerebrospinal fluid and plasma reveals new biological fingerprint of cerebral small vessel disease.","description":"Cerebral small vessel disease (cSVD) is a leading cause of stroke and dementia with no specific treatment, of which molecular mechanisms remain poorly understood. To identify potential biomarkers and therapeutic targets, we applied Mendelian randomization to examine over 2,500 proteins measured in plasma and, uniquely, cerebrospinal fluid, in relation to magnetic resonance imaging (MRI) markers of cSVD in more than 40,000 individuals. Here we show that 49 proteins are associated with MRI markers of cSVD, most prominently in cerebrospinal fluid. We highlight associations that are consistent across platforms and ancestries, and supported by complementary observational analyses, and we explore differences between fluids. The proteins are enriched in pathways related to the extracellular matri","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T03:59:47.317Z","creation":"2026-05-25T03:11:58.124Z"},"accession":"S-EPMC12705447","cross_references":{"pubmed":["41266628"],"doi":["10.1038/s43587-025-01006-w"]}}