{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Toledo B"],"funding":["ACCIÓN 1A POAI 2023-2024: BIO349_2023 (06.30.00.27.AE)","Consejería de Transformación Económica, Industria, Conocimiento y Universidades, Junta de Andalucía, Modeling Nature (MNat, project number QUAL21-11)","University of Jaen, ACCIÓN 1 PAIUJA 2021-2022: BIO349_2021 (ref: 06.30.00.27.1A)","Youth Guarantee Program\" ref: SNGJ_PTA4_M_008 Junta de Andalucía"],"pagination":["43750"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12705662"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["The tumor microenvironment (TME) plays a pivotal role in tumor initiation, progression, and the formation of pre-metastatic niches. Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense fibrotic stroma containing a significant enriched population of cancer-associated fibroblasts (CAFs). The interplay between CAFs and tumor cells is crucial in driving tumor advancement and metastasis, underscoring the potential benefits of novel therapeutic strategies targeting stromal cells to improve patient survival. Pancreatic (pro)enzymes have shown efficacy in cancer treatment. In this study, we evaluated a formulation of Trypsinogen and Chymotrypsinogen A (PRP) on a model of PDAC-CAFs dynamics. Our findings demonstrated PRP multifaceted effects, including: (i) inhibition of the acquisit"],"journal":["Scientific reports"],"pubmed_title":["Impact of pancreatic proenzymes on pancreatic ductal adenocarcinoma associated fibroblasts."],"pmcid":["PMC12705662"],"funding_grant_id":["MNat, project number QUAL21-11","BIO349_2023 (06.30.00.27.AE)","BIO349_2021 (ref: 06.30.00.27.1A","SNGJ_PTA4_M_008"],"pubmed_authors":["Toledo B","Gonzalez-Titos A","Hernandez-Camarero P","Grinan-Lison C","Giovannetti E","Peran M","Lopez-Ruiz E","Marchal JA"],"additional_accession":[]},"is_claimable":false,"name":"Impact of pancreatic proenzymes on pancreatic ductal adenocarcinoma associated fibroblasts.","description":"The tumor microenvironment (TME) plays a pivotal role in tumor initiation, progression, and the formation of pre-metastatic niches. Pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense fibrotic stroma containing a significant enriched population of cancer-associated fibroblasts (CAFs). The interplay between CAFs and tumor cells is crucial in driving tumor advancement and metastasis, underscoring the potential benefits of novel therapeutic strategies targeting stromal cells to improve patient survival. Pancreatic (pro)enzymes have shown efficacy in cancer treatment. In this study, we evaluated a formulation of Trypsinogen and Chymotrypsinogen A (PRP) on a model of PDAC-CAFs dynamics. Our findings demonstrated PRP multifaceted effects, including: (i) inhibition of the acquisit","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T15:56:45.041Z","creation":"2026-06-02T03:10:29.614Z"},"accession":"S-EPMC12705662","cross_references":{"pubmed":["41387974"],"doi":["10.1038/s41598-025-24863-2"]}}