biostudies-literatureUnknown15(1)Wang YPostprandial plasma glucose between 4 and 7.9 h is associated with the diagnosis of diabetes, diabetes mortality, and cardiovascular mortality. However, it is unknown whether 2-hour plasma glucose during the oral glucose tolerance test conducted in this postprandial period (4-7.9 h), termed as 2-h PG_{OGTT@4-7.9 h}, can accurately classify diabetes diagnosis and predict mortality risks. This study aimed to address these questions using 2,347 adult participants. Diabetes was defined as HbA_1c ≥ 6.5%, and the ability of 2-h PG_{OGTT@4-7.9 h} to classify diabetes was analyzed using receiver operating characteristic curves. Cox proportional hazards models were employed to estimate mortality hazard ratios (HRs) and 95% confidence intervals (CIs). The results showed thaScientific reports43853https://www.ebi.ac.uk/biostudies/studies/S-EPMC12705769biostudies-literaturePostprandial 2-h glucose tolerance is associated with diabetes diagnosis, diabetes mortality, and cardiovascular mortality.PMC12705769Fang YYang GPrattichizzo FWang YCeriello AfalsePostprandial 2-h glucose tolerance is associated with diabetes diagnosis, diabetes mortality, and cardiovascular mortality.Postprandial plasma glucose between 4 and 7.9 h is associated with the diagnosis of diabetes, diabetes mortality, and cardiovascular mortality. However, it is unknown whether 2-hour plasma glucose during the oral glucose tolerance test conducted in this postprandial period (4-7.9 h), termed as 2-h PG_{OGTT@4-7.9 h}, can accurately classify diabetes diagnosis and predict mortality risks. This study aimed to address these questions using 2,347 adult participants. Diabetes was defined as HbA_1c ≥ 6.5%, and the ability of 2-h PG_{OGTT@4-7.9 h} to classify diabetes was analyzed using receiver operating characteristic curves. Cox proportional hazards models were employed to estimate mortality hazard ratios (HRs) and 95% confidence intervals (CIs). The results showed tha2025-01-01T00:00:00Z2025 Dec2026-06-06T03:54:36.331Z2026-05-25T03:11:56.642ZS-EPMC127057694139842510.1038/s41598-025-28849-y