{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["135(12)"],"submitter":["Tadikonda A"],"funding":["IUSM Department of Otolaryngology-HNS"],"pubmed_abstract":["<h4>Objective</h4>Unilateral vocal fold paralysis (UVFP) due to recurrent laryngeal nerve injury (RLN) is a major cause of voice disorders. We have recently identified three biomolecules (agrin, acetylcholine, and neuregulin) with the potential to promote reinnervation after RLN injury. This study aimed to determine if a gelatin injectable with the reinnervating biomolecules will induce site-specific amplification of neurotrophic factor release and reinnervation after RLN injury in unilateral vocal fold paralysis.<h4>Methods</h4>C57BL/6 mice underwent RLN transection with the following treatment allocations: saline control (N = 16), biomolecule cocktail only (N = 16), and biomolecule-infused gelatin (N = 16). All injectables were delivered into the denervated thyroarytenoid muscle. Assessm"],"journal":["The Laryngoscope"],"pagination":["4781-4792"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12706572"],"repository":["biostudies-literature"],"pubmed_title":["Novel Biomolecule-Infused Gelatin Injectable for Treatment of Recurrent Laryngeal Nerve Injury."],"pmcid":["PMC12706572"],"pubmed_authors":["Tadikonda A","Wesson T","Halum S","Finnegan PR","Jackson C","Anekal S","Chen LW","Sobczak G","Liu JC","Egan MA"],"additional_accession":[]},"is_claimable":false,"name":"Novel Biomolecule-Infused Gelatin Injectable for Treatment of Recurrent Laryngeal Nerve Injury.","description":"<h4>Objective</h4>Unilateral vocal fold paralysis (UVFP) due to recurrent laryngeal nerve injury (RLN) is a major cause of voice disorders. We have recently identified three biomolecules (agrin, acetylcholine, and neuregulin) with the potential to promote reinnervation after RLN injury. This study aimed to determine if a gelatin injectable with the reinnervating biomolecules will induce site-specific amplification of neurotrophic factor release and reinnervation after RLN injury in unilateral vocal fold paralysis.<h4>Methods</h4>C57BL/6 mice underwent RLN transection with the following treatment allocations: saline control (N = 16), biomolecule cocktail only (N = 16), and biomolecule-infused gelatin (N = 16). All injectables were delivered into the denervated thyroarytenoid muscle. Assessm","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T03:52:34.715Z","creation":"2026-05-25T03:12:13.562Z"},"accession":"S-EPMC12706572","cross_references":{"pubmed":["40952065"],"doi":["10.1002/lary.32459"]}}