{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dori D"],"funding":["the Canadian Institutes of Health Research"],"pagination":["e70960"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12706624"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(12)"],"pubmed_abstract":["<h4>Introduction</h4>Controversial hypotheses suggest that \"suboptimal\" thyroid function - defined as higher-normal thyroid-stimulating hormone (TSH) (2.0 to 4.5 μIU/mL) or low-normal free thyroxine (FT4) - may increase risk of cognitive decline and dementia in older patients.<h4>Methods</h4>We examined this claim using data from the Canadian Comprehensive Assessment of Neurodegeneration and Dementia cohort (ages 50 to 91; cognitive statuses from unimpaired to dementia, rarer subtypes of dementia excluded). Thyroid function was categorized as \"optimal\" (TSH < 2.0 μIU/mL or FT4 ≥ 16.74 pmol/L) or \"suboptimal.\" Six hundred eighty-eight participants had TSH data, and 476 participants had FT4 data.<h4>Results</h4>Chi-squared analyses showed no significant association between \"suboptimal\" thyro"],"journal":["Alzheimer's & dementia : the journal of the Alzheimer's Association"],"pubmed_title":["Thyroid function and cognitive health: rethinking the relationship between \"suboptimal\" TSH/FT4 levels and cognitive decline."],"pmcid":["PMC12706624"],"funding_grant_id":["CNA-163902","CNA-137794","BDO-148341"],"pubmed_authors":["Chertkow H","Borrie M","Seixas-Lima B","Lahiri D","Roncero C","Dori D"],"additional_accession":[]},"is_claimable":false,"name":"Thyroid function and cognitive health: rethinking the relationship between \"suboptimal\" TSH/FT4 levels and cognitive decline.","description":"<h4>Introduction</h4>Controversial hypotheses suggest that \"suboptimal\" thyroid function - defined as higher-normal thyroid-stimulating hormone (TSH) (2.0 to 4.5 μIU/mL) or low-normal free thyroxine (FT4) - may increase risk of cognitive decline and dementia in older patients.<h4>Methods</h4>We examined this claim using data from the Canadian Comprehensive Assessment of Neurodegeneration and Dementia cohort (ages 50 to 91; cognitive statuses from unimpaired to dementia, rarer subtypes of dementia excluded). Thyroid function was categorized as \"optimal\" (TSH < 2.0 μIU/mL or FT4 ≥ 16.74 pmol/L) or \"suboptimal.\" Six hundred eighty-eight participants had TSH data, and 476 participants had FT4 data.<h4>Results</h4>Chi-squared analyses showed no significant association between \"suboptimal\" thyro","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-07T05:21:34.815Z","creation":"2026-06-07T03:07:12.216Z"},"accession":"S-EPMC12706624","cross_references":{"pubmed":["41400007"],"doi":["10.1002/alz.70960"]}}