{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["30(1)"],"submitter":["Wang H"],"pubmed_abstract":["<h4>Background</h4>As a chronic inflammatory skin disease, atopic dermatitis (AD) results from immune dysregulation, epidermal barrier dysfunction, and inflammatory microenvironment. Although long non-coding RNAs (lncRNAs) and neutrophil extracellular traps (NETs) are implicated in inflammatory diseases, the role of the DSG1-AS1/miR-125b-5p/HMGA2 axis in AD and its link to NETs formation remain unclear.<h4>Objective</h4>This research sought to explore the role of the DSG1-AS1/miR-125b-5p/HMGA2 axis in AD pathogenesis, focusing on its regulation of keratinocyte inflammation, neutrophil recruitment, and NETs formation, and evaluate its potential as a diagnostic biomarker.<h4>Methods</h4>The expression levels of DSG1-AS1, miR-125b-5p and HMGA2 were detected by real-time quantitative PCR (RT-q"],"journal":["European journal of medical research"],"pagination":["1236"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12706904"],"repository":["biostudies-literature"],"pubmed_title":["The DSG1-AS1/miR-125b-5p/HMGA2 axis is associated with the formation of neutrophil extracellular traps in atopic dermatitis."],"pmcid":["PMC12706904"],"pubmed_authors":["Ke X","Jing H","Li S","Wang H","Chen X"],"additional_accession":[]},"is_claimable":false,"name":"The DSG1-AS1/miR-125b-5p/HMGA2 axis is associated with the formation of neutrophil extracellular traps in atopic dermatitis.","description":"<h4>Background</h4>As a chronic inflammatory skin disease, atopic dermatitis (AD) results from immune dysregulation, epidermal barrier dysfunction, and inflammatory microenvironment. Although long non-coding RNAs (lncRNAs) and neutrophil extracellular traps (NETs) are implicated in inflammatory diseases, the role of the DSG1-AS1/miR-125b-5p/HMGA2 axis in AD and its link to NETs formation remain unclear.<h4>Objective</h4>This research sought to explore the role of the DSG1-AS1/miR-125b-5p/HMGA2 axis in AD pathogenesis, focusing on its regulation of keratinocyte inflammation, neutrophil recruitment, and NETs formation, and evaluate its potential as a diagnostic biomarker.<h4>Methods</h4>The expression levels of DSG1-AS1, miR-125b-5p and HMGA2 were detected by real-time quantitative PCR (RT-q","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-05-26T17:01:53.808Z","creation":"2026-05-25T03:12:03.731Z"},"accession":"S-EPMC12706904","cross_references":{"pubmed":["41398699"],"doi":["10.1186/s40001-025-03459-6"]}}