biostudies-literatureUnknown50(4)Tsiolaki A<h4>Objectives</h4>The aim of this systematic review is to compare the effectiveness of advanced platelet concentrates as regenerative endodontic therapeutic alternatives to blood clot (BC) revascularization in immature permanent necrotic teeth.<h4>Methods</h4>Randomized controlled trials (RCTs) comparing regenerative endodontic therapies using platelet-rich plasma (PRP), platelet-rich fibrin (PRF), or platelet pellet (PP) with the BC revascularization approach in immature permanent necrotic teeth were systematically searched in PubMed, Scopus, Cochrane Library, and Web of Science until May 2025. Data was extracted and analyzed both qualitatively and quantitatively. Study quality was assessed using the Cochrane Risk of Bias tool. A meta-analysis was conducted using IBM SPSS software (versiRestorative dentistry & endodonticse38https://www.ebi.ac.uk/biostudies/studies/S-EPMC12707569biostudies-literatureEvaluation of platelet concentrates in regenerative endodontics: a systematic review and meta-analysis.PMC12707569Theocharis DFardi ATsiolaki ATsitsipas NKodonas KfalseEvaluation of platelet concentrates in regenerative endodontics: a systematic review and meta-analysis.<h4>Objectives</h4>The aim of this systematic review is to compare the effectiveness of advanced platelet concentrates as regenerative endodontic therapeutic alternatives to blood clot (BC) revascularization in immature permanent necrotic teeth.<h4>Methods</h4>Randomized controlled trials (RCTs) comparing regenerative endodontic therapies using platelet-rich plasma (PRP), platelet-rich fibrin (PRF), or platelet pellet (PP) with the BC revascularization approach in immature permanent necrotic teeth were systematically searched in PubMed, Scopus, Cochrane Library, and Web of Science until May 2025. Data was extracted and analyzed both qualitatively and quantitatively. Study quality was assessed using the Cochrane Risk of Bias tool. A meta-analysis was conducted using IBM SPSS software (versi2025-01-01T00:00:00Z2025 Nov2026-06-07T05:19:17.089Z2026-06-07T03:06:44.651ZS-EPMC127075694134220810.5395/rde.2025.50.e38