{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gore JL"],"funding":["NCATS NIH HHS","Patient-Centered Outcomes Research Institute"],"pagination":["274-285"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12707586"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(4)"],"pubmed_abstract":["Purpose
To compare patient-reported and clinical outcomes between radical cystectomy (RC) and bladder-sparing therapy (BST) in patients with recurrent high-grade non-muscle-invasive bladder cancer (NMIBC).Patients and methods
This pragmatic, prospective observational cohort study was designed with patients, who selected and prioritized outcomes. Eligible adults were candidates for both RC or BST, had previous induction Bacillus Calmette-Guérin (BCG), and received their last treatment within 12 months. The primary outcome was the EORTC-QLQ-C30 physical function scale at 12 months. Secondary outcomes included other EORTC-QLQ-C30 scales, depression, anxiety, bladder cancer-specific quality of life (QOL), financial burden, and cancer-specific outcomes. Targeted maximum likeliho"],"journal":["Journal of clinical oncology : official journal of the American Society of Clinical Oncology"],"pubmed_title":["Twelve-Month Results From the CISTO Study Comparing Radical Cystectomy Versus Bladder-Sparing Therapy for Recurrent High-Grade Non-Muscle-Invasive Bladder Cancer."],"pmcid":["PMC12707586"],"funding_grant_id":["PCS-2017C3-9380","UL1 TR002319"],"pubmed_authors":["Master VA","Shore ND","Catto JWF","Rios P","Jun G","Lotan Y","Nepple KG","Roscoe LA","Woldu SL","Chisolm S","Tyson MD","Steinberg GD","Scarpato KR","Porten SP","Ritch CR","Chang SS","Lee JR","Chamie K","Garg T","Patel S","Pohar KS","Kessler LG","MacLean DB","Peyton CC","Kim SM","Riggs SB","Kamat AM","Li C","Davicioni E","Modi PK","Bassett JC","Kates MR","Comstock BA","Smith AB","Lee EK","Bivalacqua TJ","Daneshmand S","Sankin A","Wright JL","Ballard Murray MB","Montgomery JS","Almeida F","Yano M","Chen DYT","Morris DS","Nefcy C","CISTO Collaborative group","Nix JW","O'Neil BB","Gilbert SM","Sachse K","Oliver RM","Basu A","Heagerty PJ","Guzzo TJ","Malin JL","Westerman ME","Dickstein R","Gadzinski AJ","Lindsey N","Nash MG","Macleod LC","Wolff EM","Kukreja JB","Lipman R","Taylor JM","Follmer KM","Mansour AM","Lane BR","Gore JL","Mossanen M","Downs TM"],"additional_accession":[]},"is_claimable":false,"name":"Twelve-Month Results From the CISTO Study Comparing Radical Cystectomy Versus Bladder-Sparing Therapy for Recurrent High-Grade Non-Muscle-Invasive Bladder Cancer.","description":"Purpose
To compare patient-reported and clinical outcomes between radical cystectomy (RC) and bladder-sparing therapy (BST) in patients with recurrent high-grade non-muscle-invasive bladder cancer (NMIBC).Patients and methods
This pragmatic, prospective observational cohort study was designed with patients, who selected and prioritized outcomes. Eligible adults were candidates for both RC or BST, had previous induction Bacillus Calmette-Guérin (BCG), and received their last treatment within 12 months. The primary outcome was the EORTC-QLQ-C30 physical function scale at 12 months. Secondary outcomes included other EORTC-QLQ-C30 scales, depression, anxiety, bladder cancer-specific quality of life (QOL), financial burden, and cancer-specific outcomes. Targeted maximum likeliho","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Feb","modification":"2026-06-12T10:19:45.327Z","creation":"2026-06-12T03:12:00.695Z"},"accession":"S-EPMC12707586","cross_references":{"pubmed":["41397208"],"doi":["10.1200/JCO-25-01324"]}}