biostudies-literatureGore JLNCATS NIH HHSPatient-Centered Outcomes Research Institute274-285https://www.ebi.ac.uk/biostudies/studies/S-EPMC12707586biostudies-literatureUnknown44(4)<h4>Purpose</h4>To compare patient-reported and clinical outcomes between radical cystectomy (RC) and bladder-sparing therapy (BST) in patients with recurrent high-grade non-muscle-invasive bladder cancer (NMIBC).<h4>Patients and methods</h4>This pragmatic, prospective observational cohort study was designed with patients, who selected and prioritized outcomes. Eligible adults were candidates for both RC or BST, had previous induction Bacillus Calmette-Guérin (BCG), and received their last treatment within 12 months. The primary outcome was the EORTC-QLQ-C30 physical function scale at 12 months. Secondary outcomes included other EORTC-QLQ-C30 scales, depression, anxiety, bladder cancer-specific quality of life (QOL), financial burden, and cancer-specific outcomes. Targeted maximum likelihoJournal of clinical oncology : official journal of the American Society of Clinical OncologyTwelve-Month Results From the CISTO Study Comparing Radical Cystectomy Versus Bladder-Sparing Therapy for Recurrent High-Grade Non-Muscle-Invasive Bladder Cancer.PMC12707586PCS-2017C3-9380UL1 TR002319Master VAShore NDCatto JWFRios PJun GLotan YNepple KGRoscoe LAWoldu SLChisolm STyson MDSteinberg GDScarpato KRPorten SPRitch CRChang SSLee JRChamie KGarg TPatel SPohar KSKessler LGMacLean DBPeyton CCKim SMRiggs SBKamat AMLi CDavicioni EModi PKBassett JCKates MRComstock BASmith ABLee EKBivalacqua TJDaneshmand SSankin AWright JLBallard Murray MBMontgomery JSAlmeida FYano MChen DYTMorris DSNefcy CCISTO Collaborative groupNix JWO'Neil BBGilbert SMSachse KOliver RMBasu AHeagerty PJGuzzo TJMalin JLWesterman MEDickstein RGadzinski AJLindsey NNash MGMacleod LCWolff EMKukreja JBLipman RTaylor JMFollmer KMMansour AMLane BRGore JLMossanen MDowns TMfalseTwelve-Month Results From the CISTO Study Comparing Radical Cystectomy Versus Bladder-Sparing Therapy for Recurrent High-Grade Non-Muscle-Invasive Bladder Cancer.<h4>Purpose</h4>To compare patient-reported and clinical outcomes between radical cystectomy (RC) and bladder-sparing therapy (BST) in patients with recurrent high-grade non-muscle-invasive bladder cancer (NMIBC).<h4>Patients and methods</h4>This pragmatic, prospective observational cohort study was designed with patients, who selected and prioritized outcomes. Eligible adults were candidates for both RC or BST, had previous induction Bacillus Calmette-Guérin (BCG), and received their last treatment within 12 months. The primary outcome was the EORTC-QLQ-C30 physical function scale at 12 months. Secondary outcomes included other EORTC-QLQ-C30 scales, depression, anxiety, bladder cancer-specific quality of life (QOL), financial burden, and cancer-specific outcomes. Targeted maximum likeliho2026-01-01T00:00:00Z2026 Feb2026-06-12T10:19:45.327Z2026-06-12T03:12:00.695ZS-EPMC127075864139720810.1200/JCO-25-01324