biostudies-literatureUnknown5(12)Pires MCCFOpen Philanthropy ProjectSeveral tuberculosis (TB) vaccine candidates are currently advancing to late-stage clinical trials. Prisons in low-and middle-income countries harbor some of the highest rates of TB in the world, making persons deprived of liberty (PDL) an important population to prioritize for the introduction of effective vaccines. However, the inclusion in clinical trials raises significant ethical concerns due to a history of exploitation and mistreatment within medical research. To date, PDL own perspectives on participating in vaccine research have been largely overlooked. This multicenter qualitative study employed focus group (FG) discussions in seven state prisons across four of the five regions of Brazil, involving 91 incarcerated individuals (64 men and 27 female) between February and August 202PLOS global public healthe0004941https://www.ebi.ac.uk/biostudies/studies/S-EPMC12707645biostudies-literaturePerceptions of persons deprived of liberty regarding tuberculosis vaccine research.PMC12707645Pereira DBAssis LBOde Freitas GLDos Santos Pinheiro JMagalhaes MPossuelo LGBack DKAndrews JRRuffato RHeringer TACordeiro-Santos MBatista SMSantos-Melo GZDSchwarzbold PVasconcelos MPACroda MGCroda JPires MCCFLemos EFLiu YEGoncalves CCMFerreira da Silva LfalsePerceptions of persons deprived of liberty regarding tuberculosis vaccine research.Several tuberculosis (TB) vaccine candidates are currently advancing to late-stage clinical trials. Prisons in low-and middle-income countries harbor some of the highest rates of TB in the world, making persons deprived of liberty (PDL) an important population to prioritize for the introduction of effective vaccines. However, the inclusion in clinical trials raises significant ethical concerns due to a history of exploitation and mistreatment within medical research. To date, PDL own perspectives on participating in vaccine research have been largely overlooked. This multicenter qualitative study employed focus group (FG) discussions in seven state prisons across four of the five regions of Brazil, involving 91 incarcerated individuals (64 men and 27 female) between February and August 2022025-01-01T00:00:00Z20252026-06-12T10:14:36.515Z2026-06-12T03:12:10.342ZS-EPMC127076454140119910.1371/journal.pgph.0004941