biostudies-literatureUnknown6Saxena A<h4>Aim and objectives</h4>To investigate the <i>C</i>utaneous <i>S</i>igns of <i>I</i>nsulin <i>R</i>esistance, namely acanthosis nigricans (AN) and acrochordon (AC), in individuals with <i>C</i>entral <i>O</i>besity (CO-CSIR) as physical predictors of metabolic syndrome (MetS), underlying adipose tissue pathology, and consequent pathophysiological traits in South Asians.<h4>Methods</h4>In this study, 371 participants were recruited in a tertiary care facility and grouped based on the presence of cutaneous signs (AC and/or AN) and central obesity. Each participant was assessed for MetS, T2D, as well as other demographic, biochemical, and radiological parameters. Additionally, we conducted transcriptome profiling in adipose depots for selected individuals to investigate whether there are mFrontiers in clinical diabetes and healthcare1691675https://www.ebi.ac.uk/biostudies/studies/S-EPMC12708322biostudies-literatureCutaneous signs of insulin resistance with central obesity: insights into adipocentric metabolic dysfunction in South Asians.PMC12708322Gora AGupta SChoudhary PMathur SKSharma BTiwari PSaxena AMandia RLamoria RKDhakar AfalseCutaneous signs of insulin resistance with central obesity: insights into adipocentric metabolic dysfunction in South Asians.<h4>Aim and objectives</h4>To investigate the <i>C</i>utaneous <i>S</i>igns of <i>I</i>nsulin <i>R</i>esistance, namely acanthosis nigricans (AN) and acrochordon (AC), in individuals with <i>C</i>entral <i>O</i>besity (CO-CSIR) as physical predictors of metabolic syndrome (MetS), underlying adipose tissue pathology, and consequent pathophysiological traits in South Asians.<h4>Methods</h4>In this study, 371 participants were recruited in a tertiary care facility and grouped based on the presence of cutaneous signs (AC and/or AN) and central obesity. Each participant was assessed for MetS, T2D, as well as other demographic, biochemical, and radiological parameters. Additionally, we conducted transcriptome profiling in adipose depots for selected individuals to investigate whether there are m2025-01-01T00:00:00Z20252026-07-15T14:29:47.121Z2026-07-06T03:08:56.977ZS-EPMC127083224141526510.3389/fcdhc.2025.1691675