{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["478(1)"],"submitter":["Hahn RG"],"funding":["Karolinska Institute"],"pubmed_abstract":["Recent kinetic studies show that the interstitial space contains two functional fluid compartments. This study explores the prerequisites for accumulation of infused crystalloid fluid in the remote slow-exchange space (\"third fluid space¨, V<sub>t2</sub>). Volume kinetic analysis based on log likelihood mathematics was applied to retrospective data from 132 intravenous infusions in 85 healthy volunteers who received 0.6-2.5 L of crystalloid fluid over 30 min. Frequent measurements of the blood hemoglobin concentration during and after these infusions, together with the measured urine output, served as calculation inputs. Three substudies were set up to illustrate key issues regarding V<sub>t2</sub> filling. In the first of them, infusions were preceded by blood withdrawal, which is known t"],"journal":["Pflugers Archiv : European journal of physiology"],"pagination":["12"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12708698"],"repository":["biostudies-literature"],"pubmed_title":["When does the \"third fluid space\" open?"],"pmcid":["PMC12708698"],"pubmed_authors":["Hahn RG"],"additional_accession":[]},"is_claimable":false,"name":"When does the \"third fluid space\" open?","description":"Recent kinetic studies show that the interstitial space contains two functional fluid compartments. This study explores the prerequisites for accumulation of infused crystalloid fluid in the remote slow-exchange space (\"third fluid space¨, V<sub>t2</sub>). Volume kinetic analysis based on log likelihood mathematics was applied to retrospective data from 132 intravenous infusions in 85 healthy volunteers who received 0.6-2.5 L of crystalloid fluid over 30 min. Frequent measurements of the blood hemoglobin concentration during and after these infusions, together with the measured urine output, served as calculation inputs. Three substudies were set up to illustrate key issues regarding V<sub>t2</sub> filling. In the first of them, infusions were preceded by blood withdrawal, which is known t","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-16T09:42:01.456Z","creation":"2026-07-09T10:46:49.493Z"},"accession":"S-EPMC12708698","cross_references":{"pubmed":["41402554"],"doi":["10.1007/s00424-025-03135-y"]}}