{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15(1)"],"submitter":["Tas A"],"pubmed_abstract":["Revascularization decision for intermediate stenoses necessitates consideration of their hemodynamic impact. We report the use of distal coronary pressure (Pd) above proximal aortic pressure (Pa) during the early expansion period as a visual dichotomous marker (negative expansion resistance, NER) for rapid clinical decision-making. Simultaneous pressure and velocity signals were used to calculate instantaneous wave-free ratio (iFR), fractional flow reserve (FFR), hyperemic stenosis resistance (hSR), and to identify the NER. NER was defined as the Pd > Pa during the early-expansion period, which refers to early-decompression of coronary circulation marked by pressure decay (dP/dt < 0) coinciding the time-window of reduced ejection phase of systole to early diastole. Classification performan"],"journal":["Scientific reports"],"pagination":["43866"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12708762"],"repository":["biostudies-literature"],"pubmed_title":["Negative expansion resistance (NER) phenomenon predicts hemodynamically non-significant coronary lesions."],"pmcid":["PMC12708762"],"pubmed_authors":["Parker KH","Sezer M","van de Hoef TP","Kara Tas I","Tas A","Alan Y","Piek JJ"],"additional_accession":[]},"is_claimable":false,"name":"Negative expansion resistance (NER) phenomenon predicts hemodynamically non-significant coronary lesions.","description":"Revascularization decision for intermediate stenoses necessitates consideration of their hemodynamic impact. We report the use of distal coronary pressure (Pd) above proximal aortic pressure (Pa) during the early expansion period as a visual dichotomous marker (negative expansion resistance, NER) for rapid clinical decision-making. Simultaneous pressure and velocity signals were used to calculate instantaneous wave-free ratio (iFR), fractional flow reserve (FFR), hyperemic stenosis resistance (hSR), and to identify the NER. NER was defined as the Pd > Pa during the early-expansion period, which refers to early-decompression of coronary circulation marked by pressure decay (dP/dt < 0) coinciding the time-window of reduced ejection phase of systole to early diastole. Classification performan","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-07-15T14:29:38.26Z","creation":"2026-07-06T03:08:55.511Z"},"accession":"S-EPMC12708762","cross_references":{"pubmed":["41361225"],"doi":["10.1038/s41598-025-29670-3"]}}