{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lee SG"],"funding":["Ministry of Trade, Industry and Energy"],"pagination":["e327"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12708972"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["40(48)"],"pubmed_abstract":["<h4>Background</h4>The skin microbiome plays a crucial role in defending against pathogens and modulating immunity, and its dysregulation is linked to various skin conditions, including acne.<h4>Methods</h4>In this study, four previously identified strains-<i>Staphylococcus epidermidis</i> B424F-5, <i>S. epidermidis</i> BS47C-1, <i>Dermacoccus profundi</i> BS35F-3, and <i>Streptococcus salivarius</i> BS320F-4- were selected from a skin microbiome database of healthy individuals. The efficacy and safety of these strains against acne-related inflammation were evaluated using in vitro and in vivo animal model experiments.<h4>Results</h4><i>Cutibacterium acnes</i> exposure increased the expression of acne-associated inflammatory mediators-such as IL-1β, IL-6, IL-8, COX-2, iNOS, and TNF-α-parti"],"journal":["Journal of Korean medical science"],"pubmed_title":["Efficacy and Safety of Human Skin Microbiome-Derived Strains as Topical Treatment for Acne: An In Vitro and In Vivo Study."],"pmcid":["PMC12708972"],"funding_grant_id":["20024192"],"pubmed_authors":["Ham S","Lee SG","Baek Y","Lee YI","Chu J","Kim KH","Shin CH","Lee JH"],"additional_accession":[]},"is_claimable":false,"name":"Efficacy and Safety of Human Skin Microbiome-Derived Strains as Topical Treatment for Acne: An In Vitro and In Vivo Study.","description":"<h4>Background</h4>The skin microbiome plays a crucial role in defending against pathogens and modulating immunity, and its dysregulation is linked to various skin conditions, including acne.<h4>Methods</h4>In this study, four previously identified strains-<i>Staphylococcus epidermidis</i> B424F-5, <i>S. epidermidis</i> BS47C-1, <i>Dermacoccus profundi</i> BS35F-3, and <i>Streptococcus salivarius</i> BS320F-4- were selected from a skin microbiome database of healthy individuals. The efficacy and safety of these strains against acne-related inflammation were evaluated using in vitro and in vivo animal model experiments.<h4>Results</h4><i>Cutibacterium acnes</i> exposure increased the expression of acne-associated inflammatory mediators-such as IL-1β, IL-6, IL-8, COX-2, iNOS, and TNF-α-parti","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T03:57:05.563Z","creation":"2026-05-25T03:12:06.069Z"},"accession":"S-EPMC12708972","cross_references":{"pubmed":["41399266"],"doi":["10.3346/jkms.2025.40.e327"]}}