biostudies-literatureLee SGMinistry of Trade, Industry and Energye327https://www.ebi.ac.uk/biostudies/studies/S-EPMC12708972biostudies-literatureUnknown40(48)<h4>Background</h4>The skin microbiome plays a crucial role in defending against pathogens and modulating immunity, and its dysregulation is linked to various skin conditions, including acne.<h4>Methods</h4>In this study, four previously identified strains-<i>Staphylococcus epidermidis</i> B424F-5, <i>S. epidermidis</i> BS47C-1, <i>Dermacoccus profundi</i> BS35F-3, and <i>Streptococcus salivarius</i> BS320F-4- were selected from a skin microbiome database of healthy individuals. The efficacy and safety of these strains against acne-related inflammation were evaluated using in vitro and in vivo animal model experiments.<h4>Results</h4><i>Cutibacterium acnes</i> exposure increased the expression of acne-associated inflammatory mediators-such as IL-1β, IL-6, IL-8, COX-2, iNOS, and TNF-α-partiJournal of Korean medical scienceEfficacy and Safety of Human Skin Microbiome-Derived Strains as Topical Treatment for Acne: An In Vitro and In Vivo Study.PMC1270897220024192Ham SLee SGBaek YLee YIChu JKim KHShin CHLee JHfalseEfficacy and Safety of Human Skin Microbiome-Derived Strains as Topical Treatment for Acne: An In Vitro and In Vivo Study.<h4>Background</h4>The skin microbiome plays a crucial role in defending against pathogens and modulating immunity, and its dysregulation is linked to various skin conditions, including acne.<h4>Methods</h4>In this study, four previously identified strains-<i>Staphylococcus epidermidis</i> B424F-5, <i>S. epidermidis</i> BS47C-1, <i>Dermacoccus profundi</i> BS35F-3, and <i>Streptococcus salivarius</i> BS320F-4- were selected from a skin microbiome database of healthy individuals. The efficacy and safety of these strains against acne-related inflammation were evaluated using in vitro and in vivo animal model experiments.<h4>Results</h4><i>Cutibacterium acnes</i> exposure increased the expression of acne-associated inflammatory mediators-such as IL-1β, IL-6, IL-8, COX-2, iNOS, and TNF-α-parti2025-01-01T00:00:00Z2025 Dec2026-06-06T03:57:05.563Z2026-05-25T03:12:06.069ZS-EPMC127089724139926610.3346/jkms.2025.40.e327