biostudies-literatureUnknown18Kozlowska K<h4>Background</h4>Insulinomas are the most common functional pancreatic neuroendocrine tumors (pNETs). Minimally invasive approaches like endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) and ethanol ablation (EUS-EA) are emerging treatment options for small insulinomas (<2 cm).<h4>Objectives</h4>To assess the safety, efficacy, and long-term outcomes of EUS-RFA and EUS-EA in treating small pancreatic insulinomas.<h4>Design</h4>A retrospective, single-center study of nine patients diagnosed with insulinomas and treated with EUS ablation methods.<h4>Methods</h4>Nine lesions (mean size 11 mm; range: 6-19 mm) were treated with EUS-RFA (<i>n</i> = 7) or EUS-EA (<i>n</i> = 2). EUS-RFA procedures had a mean ablation time of 31 s (range: 17-69 s), while EUS-EA used a mean ethanol volTherapeutic advances in gastrointestinal endoscopy26317745251401315https://www.ebi.ac.uk/biostudies/studies/S-EPMC12708985biostudies-literatureEUS-guided radiofrequency and ethanol ablation of pancreatic insulinomas: a single-center experience.PMC12708985Wiechowska-Kozlowska ABosy-Gasior WHsino-Sito NKozlowska KPawlak KMJedruszek SfalseEUS-guided radiofrequency and ethanol ablation of pancreatic insulinomas: a single-center experience.<h4>Background</h4>Insulinomas are the most common functional pancreatic neuroendocrine tumors (pNETs). Minimally invasive approaches like endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) and ethanol ablation (EUS-EA) are emerging treatment options for small insulinomas (<2 cm).<h4>Objectives</h4>To assess the safety, efficacy, and long-term outcomes of EUS-RFA and EUS-EA in treating small pancreatic insulinomas.<h4>Design</h4>A retrospective, single-center study of nine patients diagnosed with insulinomas and treated with EUS ablation methods.<h4>Methods</h4>Nine lesions (mean size 11 mm; range: 6-19 mm) were treated with EUS-RFA (<i>n</i> = 7) or EUS-EA (<i>n</i> = 2). EUS-RFA procedures had a mean ablation time of 31 s (range: 17-69 s), while EUS-EA used a mean ethanol vol2025-01-01T00:00:00Z2025 Jan-Dec2026-06-08T05:08:55.745Z2026-06-08T03:09:10.161ZS-EPMC127089854141553210.1177/26317745251401315