{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dong W"],"funding":["Ministry of Science and Technology of the People's Republic of China"],"pagination":["295"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12709716"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["18(1)"],"pubmed_abstract":["Background
Hydroxyurea (HU) is an antitumor drug. However, HU exposure is associated with diminished ovarian reserve (DOR). Zi Chong granules, a Chinese Medicine, can protect against DOR, but little is known regarding its underlying mechanisms of DOR treatment, and thus the target of the present study.Methods
Seventy-two female Kunming (KM) mice (4-6 weeks old) were randomly divided into three groups: the control group (Con), the hydroxyurea group (HU), and the Zi Chong group (ZC). The Con group received saline, while the HU and ZC groups were administered hydroxyurea (400 mg/kg/d) by gavage for 21 days to induce diminished ovarian reserve (DOR). Subsequently, the Con and HU groups were given saline, while the ZC group was treated with Zi Chong granules (2.72 g/kg/d) for 15"],"journal":["Journal of ovarian research"],"pubmed_title":["Therapeutic mechanisms of Zi Chong granules against hydroxyurea-induced diminished ovarian reserve based on integrated multi-omics analyses."],"pmcid":["PMC12709716"],"funding_grant_id":["2018YFC1704305"],"pubmed_authors":["Liu Y","Dong W","Liu Z","Wan Q","Lu H","Guo X","Xie L","Liu S","Chen R"],"additional_accession":[]},"is_claimable":false,"name":"Therapeutic mechanisms of Zi Chong granules against hydroxyurea-induced diminished ovarian reserve based on integrated multi-omics analyses.","description":"Background
Hydroxyurea (HU) is an antitumor drug. However, HU exposure is associated with diminished ovarian reserve (DOR). Zi Chong granules, a Chinese Medicine, can protect against DOR, but little is known regarding its underlying mechanisms of DOR treatment, and thus the target of the present study.Methods
Seventy-two female Kunming (KM) mice (4-6 weeks old) were randomly divided into three groups: the control group (Con), the hydroxyurea group (HU), and the Zi Chong group (ZC). The Con group received saline, while the HU and ZC groups were administered hydroxyurea (400 mg/kg/d) by gavage for 21 days to induce diminished ovarian reserve (DOR). Subsequently, the Con and HU groups were given saline, while the ZC group was treated with Zi Chong granules (2.72 g/kg/d) for 15","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T04:16:55.769Z","creation":"2026-05-25T03:11:51.04Z"},"accession":"S-EPMC12709716","cross_references":{"pubmed":["41402854"],"doi":["10.1186/s13048-025-01846-5"]}}