{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yu H"],"funding":["the Research Funds of Joint Research Center for Occupational Medicine and Health of IHM","the Qingdao Natural Science Foundation","the National Natural Science Foundation of China"],"pagination":["35"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12709752"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(1)"],"pubmed_abstract":["Environmental pollutants like PM<sub>2.5</sub> threaten hematopoietic homeostasis, yet how real-world exposure disrupts blood cell production, especially locally in the lung and systemically in the bone marrow (BM), remains poorly understood. Previous studies often used artificial particles or lacked mechanistic insights into systemic effects. Hypoxia-inducible factor-1alpha (HIF-1α) is essential for hematopoietic stem cell (HSC) maintenance. Herein, we utilized a real-ambient PM<sub>2.5</sub> exposure system and conducted a detailed characterization of hematopoietic and downstream immune cell populations in mice with myeloid lineage-specific knockout of HIF-1α (mHIF-1α<sup>-/-</sup>) and their wild-type littermate controls. Our findings demonstrate that real-ambient PM<sub>2.5</sub> expos"],"journal":["Particle and fibre toxicology"],"pubmed_title":["Real-ambient PM&lt;sub&gt;2.5&lt;/sub&gt; exposure disrupts hematopoietic homeostasis via HIF-1α-driven myeloid skewing and promotes organ inflammation."],"pmcid":["PMC12709752"],"funding_grant_id":["OMH-2024-011","82473674, 82241086,U24A20772","24-4-4-zrjj-157-jch"],"pubmed_authors":["Zheng Y","Jin X","Jiang G","Chen Y","Wang Y","Tang G","Zhang R","Qu G","Yu H","Li M"],"additional_accession":[]},"is_claimable":false,"name":"Real-ambient PM&lt;sub&gt;2.5&lt;/sub&gt; exposure disrupts hematopoietic homeostasis via HIF-1α-driven myeloid skewing and promotes organ inflammation.","description":"Environmental pollutants like PM<sub>2.5</sub> threaten hematopoietic homeostasis, yet how real-world exposure disrupts blood cell production, especially locally in the lung and systemically in the bone marrow (BM), remains poorly understood. Previous studies often used artificial particles or lacked mechanistic insights into systemic effects. Hypoxia-inducible factor-1alpha (HIF-1α) is essential for hematopoietic stem cell (HSC) maintenance. Herein, we utilized a real-ambient PM<sub>2.5</sub> exposure system and conducted a detailed characterization of hematopoietic and downstream immune cell populations in mice with myeloid lineage-specific knockout of HIF-1α (mHIF-1α<sup>-/-</sup>) and their wild-type littermate controls. Our findings demonstrate that real-ambient PM<sub>2.5</sub> expos","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T04:10:05.939Z","creation":"2026-05-25T03:12:06.093Z"},"accession":"S-EPMC12709752","cross_references":{"pubmed":["41398968"],"doi":["10.1186/s12989-025-00654-5"]}}