biostudies-literatureLowor GNINDS NIH HHSNational Institutes of HealthNIH HHS2604-2614https://www.ebi.ac.uk/biostudies/studies/S-EPMC12710177biostudies-literatureUnknown40(12)<h4>Background</h4>Tourette syndrome (TS) is a neurodevelopmental disorder characterized by intermittent involuntary, repetitive movements and vocalizations collectively referred to as tics. For participants with severe tics who are resistant to medication and behavioral therapy, deep brain stimulation (DBS) has emerged as a potential treatment. Suboptimal animal models and shortcomings in anatomical imaging have collectively hindered progress in understanding the neurophysiological basis of human tic generation.<h4>Objectives</h4>This study investigates the mechanisms underlying tic generation across two DBS targets with simultaneous recordings-the centromedian thalamus (CM) and anterior globus pallidus internus (aGPi)-and their interactions.<h4>Methods</h4>Six participants with TS underwMovement disorders : official journal of the Movement Disorder SocietyThe CM-aGPi Network in the Generation of Tics in Tourette Syndrome.PMC127101771 UH3 NS119844-01A11 UH3 NS119844‐01A1UH3 NS119844Gomez JFoote KGunduz AButson COkun MSLowor GHook MfalseThe CM-aGPi Network in the Generation of Tics in Tourette Syndrome.<h4>Background</h4>Tourette syndrome (TS) is a neurodevelopmental disorder characterized by intermittent involuntary, repetitive movements and vocalizations collectively referred to as tics. For participants with severe tics who are resistant to medication and behavioral therapy, deep brain stimulation (DBS) has emerged as a potential treatment. Suboptimal animal models and shortcomings in anatomical imaging have collectively hindered progress in understanding the neurophysiological basis of human tic generation.<h4>Objectives</h4>This study investigates the mechanisms underlying tic generation across two DBS targets with simultaneous recordings-the centromedian thalamus (CM) and anterior globus pallidus internus (aGPi)-and their interactions.<h4>Methods</h4>Six participants with TS underw2025-01-01T00:00:00Z2025 Dec2026-07-15T11:14:20.219Z2026-07-04T03:12:20.419ZS-EPMC127101774097725510.1002/mds.70043