{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["40(12)"],"submitter":["Leta V"],"funding":["Vetenskapsrådet","Skåne Health Care Region","NIHR Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London","Parkinson&apos;s UK","Faculty of Medicine at Lund University (Multipark)","Symprove Ltd","Swedish Research Council","Swedish Parkinson Academy","Swedish Parkinson Foundation","Parkinson's UK"],"pubmed_abstract":["<h4>Background</h4>Gut dysbiosis and gut-brain-axis involvement in people with Parkinson's disease (PwP) support the use of gut-microbiota-modulating interventions. Probiotics may help manage constipation in PwP; however, mechanisms underpinning additional beneficial properties are unknown.<h4>Objective</h4>The aim was evaluating the effects of a probiotic (Lacticaseibacillus rhamnosus, Lactobacillus acidophilus, Lactiplantibacillus plantarum and Enterococcus faecium) on gut microbiota, inflammation, motor and non-motor symptoms (NMS) in PwP and constipation.<h4>Methods</h4>In this multicenter, randomized, double-blind, placebo-controlled trial (NCT05146921), PwP and constipation were randomized (1:1) to receive either the probiotic (4.08 × 10<sup>8</sup> CFU/mL) or placebo orally (70 mL/d"],"journal":["Movement disorders : official journal of the Movement Disorder Society"],"pagination":["2710-2721"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12710184"],"repository":["biostudies-literature"],"pubmed_title":["Effects of a Four-Strain Probiotic on Gut Microbiota, Inflammation, and Symptoms in Parkinson's Disease: A Randomized Clinical Trial."],"pmcid":["PMC12710184"],"pubmed_authors":["Parry M","Falup-Pecurariu C","Sauerbier A","Podlewska A","Pariante CM","Leta V","Vauzour D","Odin P","Jernstedt F","Moretto E","Rodriguez Blazquez C","Sportelli C","Borsini A","Timpka J","Rodriguez-Mateos A","van Vliet T","Rizos A","Batzu L","Trivedi D","van Wamelen DJ","Chung-Faye G","Mandal G","Gaisford S","Bonder AL","Le Gall G","Rosqvist K","Marsaux B","Staunton J","Ray Chaudhuri K","Ghyselinck J","Zinzalias P"],"additional_accession":[]},"is_claimable":false,"name":"Effects of a Four-Strain Probiotic on Gut Microbiota, Inflammation, and Symptoms in Parkinson's Disease: A Randomized Clinical Trial.","description":"<h4>Background</h4>Gut dysbiosis and gut-brain-axis involvement in people with Parkinson's disease (PwP) support the use of gut-microbiota-modulating interventions. Probiotics may help manage constipation in PwP; however, mechanisms underpinning additional beneficial properties are unknown.<h4>Objective</h4>The aim was evaluating the effects of a probiotic (Lacticaseibacillus rhamnosus, Lactobacillus acidophilus, Lactiplantibacillus plantarum and Enterococcus faecium) on gut microbiota, inflammation, motor and non-motor symptoms (NMS) in PwP and constipation.<h4>Methods</h4>In this multicenter, randomized, double-blind, placebo-controlled trial (NCT05146921), PwP and constipation were randomized (1:1) to receive either the probiotic (4.08 × 10<sup>8</sup> CFU/mL) or placebo orally (70 mL/d","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T04:17:41.984Z","creation":"2026-05-25T03:11:55.496Z"},"accession":"S-EPMC12710184","cross_references":{"pubmed":["41126787"],"doi":["10.1002/mds.70047"]}}