biostudies-literatureUnknown15(1)Cork DP<b>Background:</b> The impact of significant tricuspid regurgitation (sTR) on healthcare costs and utilization in real-world populations remains understudied. <b>Aim:</b> Describe healthcare costs and utilization before and after development of sTR and describe differences by patient demographic characteristics. <b>Materials & methods:</b> We conducted a retrospective, longitudinal descriptive study using a large database containing electronic health record and insurance claims data for US patients. Healthcare costs and utilization are summarized for up to 3 years prior to sTR and for 1 year after sTR. <b>Results:</b> Costs and utilization increased in the 3 years leading up to and the year after sTR. Costs were higher for patients who were: aged 50-79 years, male, and Black or Hispanic (pJournal of comparative effectiveness researche250146https://www.ebi.ac.uk/biostudies/studies/S-EPMC12711070biostudies-literatureHealthcare cost and utilization before and after the development of significant tricuspid regurgitation by age, sex and race.PMC12711070Cork DPKemp LGaba PMurphy SMMollenkopf SYeh RWMedina FDratch AHorn RBarker CfalseHealthcare cost and utilization before and after the development of significant tricuspid regurgitation by age, sex and race.<b>Background:</b> The impact of significant tricuspid regurgitation (sTR) on healthcare costs and utilization in real-world populations remains understudied. <b>Aim:</b> Describe healthcare costs and utilization before and after development of sTR and describe differences by patient demographic characteristics. <b>Materials & methods:</b> We conducted a retrospective, longitudinal descriptive study using a large database containing electronic health record and insurance claims data for US patients. Healthcare costs and utilization are summarized for up to 3 years prior to sTR and for 1 year after sTR. <b>Results:</b> Costs and utilization increased in the 3 years leading up to and the year after sTR. Costs were higher for patients who were: aged 50-79 years, male, and Black or Hispanic (p2026-01-01T00:00:00Z2026 Jan2026-06-06T03:56:47.811Z2026-05-25T03:12:04.552ZS-EPMC127110704137875310.57264/cer-2025-0146