biostudies-literatureUnknown15(1)Medina F<b>Background:</b> The impact of race and ethnicity on prognosis and clinical outcomes in patients with significant tricuspid regurgitation (sTR) is not well understood. <b>Aim:</b> Describe healthcare utilization trends preceding the development of sTR and assess clinical outcomes 1-year post-sTR status by race and ethnicity. <b>Materials & methods:</b> We conducted a retrospective, longitudinal descriptive study using data from a large database containing electronic health record and insurance claims information. We employed multivariate modeling to assess the relationship between 1-year clinical outcomes and mutually exclusive race/ethnicity groups and other baseline factors. <b>Results:</b> Black patients were more likely to be identified as having sTR as inpatients when compared with Journal of comparative effectiveness researche250156https://www.ebi.ac.uk/biostudies/studies/S-EPMC12711072biostudies-literatureRacial and ethnic differences in diagnosis, healthcare utilization and 1-year outcomes for patients with significant tricuspid regurgitation.PMC12711072Cork DPKemp LGaba PMurphy SMMollenkopf SYeh RWMedina FDratch AHorn RBarker CfalseRacial and ethnic differences in diagnosis, healthcare utilization and 1-year outcomes for patients with significant tricuspid regurgitation.<b>Background:</b> The impact of race and ethnicity on prognosis and clinical outcomes in patients with significant tricuspid regurgitation (sTR) is not well understood. <b>Aim:</b> Describe healthcare utilization trends preceding the development of sTR and assess clinical outcomes 1-year post-sTR status by race and ethnicity. <b>Materials & methods:</b> We conducted a retrospective, longitudinal descriptive study using data from a large database containing electronic health record and insurance claims information. We employed multivariate modeling to assess the relationship between 1-year clinical outcomes and mutually exclusive race/ethnicity groups and other baseline factors. <b>Results:</b> Black patients were more likely to be identified as having sTR as inpatients when compared with 2026-01-01T00:00:00Z2026 Jan2026-06-06T04:14:41.571Z2026-05-25T03:12:09.91ZS-EPMC127110724137874810.57264/cer-2025-0156