biostudies-literatureUnknown13(12)Haddock NT<h4>Background</h4>Breast reconstruction after mastectomy improves quality of life for breast cancer patients. As more late-stage patients undergo reconstruction, it is essential to understand how treatment regimens and radiation impact outcomes. This study compared early- and late-stage breast cancer patients, examining comorbidities, reconstructive details, complications, and satisfaction.<h4>Methods</h4>A total of 989 patients (903 early-stage; 86 late-stage) who underwent breast reconstruction between January 2011 and February 2025 were reviewed. Cancer staging followed the National Cancer Institute definitions: early-stage (I-IIIA) and late-stage (IIIB-IV).<h4>Results</h4>Late-stage patients had higher rates of diabetes (<i>P</i> = 0.003), neoadjuvant chemotherapy (<i>P</i> < 0.001), Plastic and reconstructive surgery. Global opene7361https://www.ebi.ac.uk/biostudies/studies/S-EPMC12711366biostudies-literatureExploring Breast Reconstruction in Late-stage Breast Cancer Patients.PMC12711366Haddock NTTroia TCTeotia SSKim LJfalseExploring Breast Reconstruction in Late-stage Breast Cancer Patients.<h4>Background</h4>Breast reconstruction after mastectomy improves quality of life for breast cancer patients. As more late-stage patients undergo reconstruction, it is essential to understand how treatment regimens and radiation impact outcomes. This study compared early- and late-stage breast cancer patients, examining comorbidities, reconstructive details, complications, and satisfaction.<h4>Methods</h4>A total of 989 patients (903 early-stage; 86 late-stage) who underwent breast reconstruction between January 2011 and February 2025 were reviewed. Cancer staging followed the National Cancer Institute definitions: early-stage (I-IIIA) and late-stage (IIIB-IV).<h4>Results</h4>Late-stage patients had higher rates of diabetes (<i>P</i> = 0.003), neoadjuvant chemotherapy (<i>P</i> < 0.001), 2025-01-01T00:00:00Z2025 Dec2026-06-07T05:26:20.374Z2026-06-07T03:07:13.257ZS-EPMC127113664141559710.1097/GOX.0000000000007361