{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shin HY"],"funding":["Institute of Civil-Military Technology Cooperation"],"pagination":["44014"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12711946"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["To overcome cross-species immunological barriers, researchers utilize gene editing to remove the expression of three major carbohydrate xenoantigens (α-Gal, Neu5Gc, and Sd(a)) and insert genes, such as human protective genes (hCD55 and hCD39). This study aimed to investigate the mechanisms underlying long-term hepatic injury following xenotransfusion of genetically modified pig red blood cells (pRBCs). We xenotransfused pRBCs genetically engineered with GGTA1<sup>-/-</sup>(α-Gal <sup>-)</sup>; CMAH<sup>-/-</sup>(Neu5Gc<sup>-</sup>); β4GALNT2<sup>-/-</sup>(Sd(a) <sup>-</sup>); hCD55; hCD39 into a non-human primate (NHP) model of acute hemorrhage hemolysis and evaluated the long-term immune response to xenogeneic RBCs in the liver, a key organ for RBC metabolism. Immediately after xenotransf"],"journal":["Scientific reports"],"pubmed_title":["Hemolysis-induced hepatic ferroptosis following xenotransfusion of genetically modified pig red blood cells."],"pmcid":["PMC12711946"],"funding_grant_id":["22-CM-EC-18"],"pubmed_authors":["Shin HY","Jang YJ","Ko N","Kang GH","Park SR","Kim HS","Lee JY","Shim J","Hwang JH"],"additional_accession":[]},"is_claimable":false,"name":"Hemolysis-induced hepatic ferroptosis following xenotransfusion of genetically modified pig red blood cells.","description":"To overcome cross-species immunological barriers, researchers utilize gene editing to remove the expression of three major carbohydrate xenoantigens (α-Gal, Neu5Gc, and Sd(a)) and insert genes, such as human protective genes (hCD55 and hCD39). This study aimed to investigate the mechanisms underlying long-term hepatic injury following xenotransfusion of genetically modified pig red blood cells (pRBCs). We xenotransfused pRBCs genetically engineered with GGTA1<sup>-/-</sup>(α-Gal <sup>-)</sup>; CMAH<sup>-/-</sup>(Neu5Gc<sup>-</sup>); β4GALNT2<sup>-/-</sup>(Sd(a) <sup>-</sup>); hCD55; hCD39 into a non-human primate (NHP) model of acute hemorrhage hemolysis and evaluated the long-term immune response to xenogeneic RBCs in the liver, a key organ for RBC metabolism. Immediately after xenotransf","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-10T05:18:21.803Z","creation":"2026-06-10T03:07:39.969Z"},"accession":"S-EPMC12711946","cross_references":{"pubmed":["41402454"],"doi":["10.1038/s41598-025-30021-5"]}}