biostudies-literatureWang GBasic Research Special Project of Key Research Projects in Higher Education Institutions in Henan ProvinceNational Natural Science Foundation of ChinaProgram for Innovative Research Team (in Science and Technology) in University of Henan ProvinceNatural Science Foundation of Henane12281https://www.ebi.ac.uk/biostudies/studies/S-EPMC12713043biostudies-literatureUnknown12(47)Rheumatoid arthritis (RA) is closely associated with intestinal microbiota dysbiosis, highlighting the therapeutic potential of targeting the microbiota-gut-joint axis. Current interventions often overlook the cascade nature of reactive oxygen species (ROS) generation in driving intestinal and systemic inflammation. Herein, a valence-engineered CeO_X-based nanozyme with self-cascade catalytic activity is developed, mimicking sequential oxidase-superoxide dismutase-peroxidase functions to enable continuous ROS scavenging while minimizing oxygen generation. By precisely tuning Ce³⁺/Ce⁴⁺ ratios from 0.27 to 0.93 through Au deposition (0.23 wt.%→5.2 wt.%), Dual functionality is achieved: 1) enhanced oxygen vacancy generation (71.4%) for efficient ROS scavenging Advanced science (Weinheim, Baden-Wurttemberg, Germany)Structure-Tailoring Cerium Nanozymes with Self-Cascade ROS Scavenging Catalysis Modulate the Microbiota-Gut-Joint Axis for Rheumatoid Arthritis Therapy.PMC127130432210708924230042121024ZX00923IRTSTHN00252271251U21A20314Ding SZhang XXiao YZhang HGuo WYan DWang GMa JNi TZhu BWang YfalseStructure-Tailoring Cerium Nanozymes with Self-Cascade ROS Scavenging Catalysis Modulate the Microbiota-Gut-Joint Axis for Rheumatoid Arthritis Therapy.Rheumatoid arthritis (RA) is closely associated with intestinal microbiota dysbiosis, highlighting the therapeutic potential of targeting the microbiota-gut-joint axis. Current interventions often overlook the cascade nature of reactive oxygen species (ROS) generation in driving intestinal and systemic inflammation. Herein, a valence-engineered CeO_X-based nanozyme with self-cascade catalytic activity is developed, mimicking sequential oxidase-superoxide dismutase-peroxidase functions to enable continuous ROS scavenging while minimizing oxygen generation. By precisely tuning Ce³⁺/Ce⁴⁺ ratios from 0.27 to 0.93 through Au deposition (0.23 wt.%→5.2 wt.%), Dual functionality is achieved: 1) enhanced oxygen vacancy generation (71.4%) for efficient ROS scavenging 2025-01-01T00:00:00Z2025 Dec2026-06-08T05:20:36.847Z2026-06-08T03:08:46.094ZS-EPMC127130434102435510.1002/advs.202512281