biostudies-literatureUnknown12(12)Huang RContinental-scale isoscapes of tree-ring oxygen isotopes (δ¹⁸O_TR) are crucial for understanding atmospheric circulation dynamics, interpreting climatic significance, and tracing wood provenance. However, continental-scale δ¹⁸O_TR isoscapes remain underdeveloped. We compiled 313 multi-year averaged δ¹⁸O_TR records across Asia and generated isoscapes using two machine learning approaches: XGBoost and Random Forest. Results reveal a 'sandwich' pattern: depleted values at high (>50°N) and low (<30°N) latitudes, enriched values at mid-latitudes (30°N-50°N). This pattern closely resembles the distribution of precipitation δ¹⁸O (δ¹⁸O_P). Correlation and commonality analyses confirm δ¹⁸O_P as the primary driver of δ¹⁸O_TR isoscape patterns across Asia. Continental-scale δ¹⁸O_TR-elevation relationships are generally insignificant, except in Indian Summer Monsoon regions showing significant negative correlations (<i>r</i> = -0.69, <i>p</i> < 0.05). These findings suggest that δ¹⁸O-based paleoaltimetry reconstructions work best in regions with dominant moisture sources such as Indian Summer Monsoon regions. This study provides Asia's first continental-scale δ¹⁸O_TR isoscapes, establishing a foundation for atmospheric circulation and dendroprovenancing research.National science reviewnwaf481https://www.ebi.ac.uk/biostudies/studies/S-EPMC12713636biostudies-literatureAsian continental isoscapes of tree-ring δ&lt;sup&gt;18&lt;/sup&gt;O: implications for paleoclimate and paleoenvironment.PMC12713636Liu YGrießinger JGuo ZMeier WJZhao QXu CAn WHuang RZhao YfalseAsian continental isoscapes of tree-ring δ&lt;sup&gt;18&lt;/sup&gt;O: implications for paleoclimate and paleoenvironment.Continental-scale isoscapes of tree-ring oxygen isotopes (δ¹⁸O_TR) are crucial for understanding atmospheric circulation dynamics, interpreting climatic significance, and tracing wood provenance. However, continental-scale δ¹⁸O_TR isoscapes remain underdeveloped. We compiled 313 multi-year averaged δ¹⁸O_TR records across Asia and generated isoscapes using two machine learning approaches: XGBoost and Random Forest. Results reveal a 'sandwich' pattern: depleted values at high (>50°N) and low (<30°N) latitudes, enriched values at mid-latitudes (30°N-50°N). This pattern closely resembles the distribution of precipitation δ¹⁸O (δ¹⁸O_P). Correlation and commonality analyses confirm δ¹⁸O_P as the primary driver of δ¹⁸O_TR isoscape patterns across Asia. Continental-scale δ¹⁸O_TR-elevation relationships are generally insignificant, except in Indian Summer Monsoon regions showing significant negative correlations (<i>r</i> = -0.69, <i>p</i> < 0.05). These findings suggest that δ¹⁸O-based paleoaltimetry reconstructions work best in regions with dominant moisture sources such as Indian Summer Monsoon regions. This study provides Asia's first continental-scale δ¹⁸O_TR isoscapes, establishing a foundation for atmospheric circulation and dendroprovenancing research.2025-01-01T00:00:00Z2025 Dec2026-06-06T04:49:01.671Z2026-05-25T03:12:11.806ZS-EPMC127136364142569710.1093/nsr/nwaf481