biostudies-literatureUnknown9Tung HYArecoline, which is a primary alkaloid in areca nuts, contributes in key ways to the development of oral submucous fibrosis and the subsequent oral cancer through the induction of oxidative stress, promotion of fibrosis, and activation of oncogenic signaling. Salvianolic acid B (SAB) is the most abundant water-soluble phenolic compound found in <i>Salvia miltiorrhiza</i> Bunge. SAB appears to have the potential to mitigate the effects of arecoline. However, the interaction between SAB and arecoline in oral cancer has been less frequently discussed. Therefore, we conducted this study in which SCC-4 tongue cancer cells were treated with arecoline alone or in combination with SAB. The effects on collagen contraction, cell migration, reactive oxygen species (ROS) production, and transcriptomicCurrent research in pharmacology and drug discovery100241https://www.ebi.ac.uk/biostudies/studies/S-EPMC12719042biostudies-literatureSalvianolic acid B decreases oxidative stress and alleviates the tumor-promoting effects of arecoline in oral cancer.PMC12719042Ye YLLin CMTung HYShi LSfalseSalvianolic acid B decreases oxidative stress and alleviates the tumor-promoting effects of arecoline in oral cancer.Arecoline, which is a primary alkaloid in areca nuts, contributes in key ways to the development of oral submucous fibrosis and the subsequent oral cancer through the induction of oxidative stress, promotion of fibrosis, and activation of oncogenic signaling. Salvianolic acid B (SAB) is the most abundant water-soluble phenolic compound found in <i>Salvia miltiorrhiza</i> Bunge. SAB appears to have the potential to mitigate the effects of arecoline. However, the interaction between SAB and arecoline in oral cancer has been less frequently discussed. Therefore, we conducted this study in which SCC-4 tongue cancer cells were treated with arecoline alone or in combination with SAB. The effects on collagen contraction, cell migration, reactive oxygen species (ROS) production, and transcriptomic2025-01-01T00:00:00Z20252026-06-06T05:24:29.145Z2026-05-26T03:12:15.14ZS-EPMC127190424143914110.1016/j.crphar.2025.100241