{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["de Freitas Galvao RL"],"funding":["Governo Brasil","Ministério da Ciência, Tecnologia, Inovações e Comunicações","Foundation for Scientific and Technological Development and Support of Ceará","National Council for Scientific and Technological Development","Ministério da Ciência, Tecnologia e Inovação"],"pagination":["100628"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12719093"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["29"],"pubmed_abstract":["This study evaluated the efficacy of different treatment regimens with PZQ against Schistosoma mansoni infection. Residents of the Patioba and Colônia Miranda villages (Sergipe, Brazil) with a confirmed diagnosis of S. mansoni infection were randomized into one of the study groups and treated with a standard dose of PZQ (Group 1); with two doses spaced 24 hours apart (Group 2); or with two doses spaced 30 days apart (Group 3). Efficacy was assessed 30 days after the final treatment, based on the detection of eggs in feces using the Kato-Katz (KK) method and on the detection of CAA in urine using the Up-Converting Particle Lateral Flow (UCP-LF) assay. A total of 88 participants, who tested positive for infection by KK and UCP-LF CAA at baseline, were included in the statistical analysis. Cu"],"journal":["International journal for parasitology. Drugs and drug resistance"],"pubmed_title":["Evaluating the efficacy of different praziquantel treatment regimens using egg and circulating anodic antigen (CAA) detection methods in a Schistosoma mansoni endemic area in northeastern Brazil."],"pmcid":["PMC12719093"],"funding_grant_id":["BMD-0008-01273.01.01/22","18/2021","404966/2021","404966/2021-7/CNPq/MCTI/FNDCT N\\u00B0 18/2021"],"pubmed_authors":["da Silva AM","Barbosa L","van Dam GJ","de Freitas Galvao RL","Pinheiro MCC","de Moraes Bezerra FS","Corstjens PLAM","Hoekstra PT","Cesar Souza Sa SL"],"additional_accession":[]},"is_claimable":false,"name":"Evaluating the efficacy of different praziquantel treatment regimens using egg and circulating anodic antigen (CAA) detection methods in a Schistosoma mansoni endemic area in northeastern Brazil.","description":"This study evaluated the efficacy of different treatment regimens with PZQ against Schistosoma mansoni infection. Residents of the Patioba and Colônia Miranda villages (Sergipe, Brazil) with a confirmed diagnosis of S. mansoni infection were randomized into one of the study groups and treated with a standard dose of PZQ (Group 1); with two doses spaced 24 hours apart (Group 2); or with two doses spaced 30 days apart (Group 3). Efficacy was assessed 30 days after the final treatment, based on the detection of eggs in feces using the Kato-Katz (KK) method and on the detection of CAA in urine using the Up-Converting Particle Lateral Flow (UCP-LF) assay. A total of 88 participants, who tested positive for infection by KK and UCP-LF CAA at baseline, were included in the statistical analysis. Cu","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-08T05:27:43.402Z","creation":"2026-06-08T03:08:55.703Z"},"accession":"S-EPMC12719093","cross_references":{"pubmed":["41337908"],"doi":["10.1016/j.ijpddr.2025.100628"]}}