biostudies-literaturede Freitas Galvao RLGoverno BrasilMinistério da Ciência, Tecnologia, Inovações e ComunicaçõesFoundation for Scientific and Technological Development and Support of CearáNational Council for Scientific and Technological DevelopmentMinistério da Ciência, Tecnologia e Inovação100628https://www.ebi.ac.uk/biostudies/studies/S-EPMC12719093biostudies-literatureUnknown29This study evaluated the efficacy of different treatment regimens with PZQ against Schistosoma mansoni infection. Residents of the Patioba and Colônia Miranda villages (Sergipe, Brazil) with a confirmed diagnosis of S. mansoni infection were randomized into one of the study groups and treated with a standard dose of PZQ (Group 1); with two doses spaced 24 hours apart (Group 2); or with two doses spaced 30 days apart (Group 3). Efficacy was assessed 30 days after the final treatment, based on the detection of eggs in feces using the Kato-Katz (KK) method and on the detection of CAA in urine using the Up-Converting Particle Lateral Flow (UCP-LF) assay. A total of 88 participants, who tested positive for infection by KK and UCP-LF CAA at baseline, were included in the statistical analysis. CuInternational journal for parasitology. Drugs and drug resistanceEvaluating the efficacy of different praziquantel treatment regimens using egg and circulating anodic antigen (CAA) detection methods in a Schistosoma mansoni endemic area in northeastern Brazil.PMC12719093BMD-0008-01273.01.01/2218/2021404966/2021404966/2021-7/CNPq/MCTI/FNDCT N\u00B0 18/2021da Silva AMBarbosa Lvan Dam GJde Freitas Galvao RLPinheiro MCCde Moraes Bezerra FSCorstjens PLAMHoekstra PTCesar Souza Sa SLfalseEvaluating the efficacy of different praziquantel treatment regimens using egg and circulating anodic antigen (CAA) detection methods in a Schistosoma mansoni endemic area in northeastern Brazil.This study evaluated the efficacy of different treatment regimens with PZQ against Schistosoma mansoni infection. Residents of the Patioba and Colônia Miranda villages (Sergipe, Brazil) with a confirmed diagnosis of S. mansoni infection were randomized into one of the study groups and treated with a standard dose of PZQ (Group 1); with two doses spaced 24 hours apart (Group 2); or with two doses spaced 30 days apart (Group 3). Efficacy was assessed 30 days after the final treatment, based on the detection of eggs in feces using the Kato-Katz (KK) method and on the detection of CAA in urine using the Up-Converting Particle Lateral Flow (UCP-LF) assay. A total of 88 participants, who tested positive for infection by KK and UCP-LF CAA at baseline, were included in the statistical analysis. Cu2025-01-01T00:00:00Z2025 Dec2026-06-08T05:27:43.402Z2026-06-08T03:08:55.703ZS-EPMC127190934133790810.1016/j.ijpddr.2025.100628