{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["35"],"submitter":["Liu X"],"pubmed_abstract":["Choroidal neovascularization (CNV), characterized by abnormal vessel growth and vascular leakage, is the hallmark of wet age-related macular degeneration (wAMD) and a leading cause of irreversible vision loss. Although anti-vascular endothelial growth factor (VEGF) therapies remain the current standard, their frequent administration and limited long-term efficacy highlight the need for novel treatments. Here, we developed a miR-22-3p-loaded tetrahedral framework nucleic acids (tFNAs-miR22) nanostructure and evaluated its efficacy in CNV suppression. The nanocomplex was structurally validated, exhibiting high assembly fidelity and superior intraocular stability compared to serum conditions. In a laser-induced CNV mouse model, a single intravitreal injection of tFNAs-miR22 significantly redu"],"journal":["Materials today. Bio"],"pagination":["102578"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12719782"],"repository":["biostudies-literature"],"pubmed_title":["Sustained suppression of choroidal neovascularization by intraocularly stable tetrahedral network encapsulated miR-22-3p."],"pmcid":["PMC12719782"],"pubmed_authors":["Liu X","Cai T","Ding X","Wang Q","Li S","Huang J","Chen L","Yu G","Chen Y","Wang Y","Luo D"],"additional_accession":[]},"is_claimable":false,"name":"Sustained suppression of choroidal neovascularization by intraocularly stable tetrahedral network encapsulated miR-22-3p.","description":"Choroidal neovascularization (CNV), characterized by abnormal vessel growth and vascular leakage, is the hallmark of wet age-related macular degeneration (wAMD) and a leading cause of irreversible vision loss. Although anti-vascular endothelial growth factor (VEGF) therapies remain the current standard, their frequent administration and limited long-term efficacy highlight the need for novel treatments. Here, we developed a miR-22-3p-loaded tetrahedral framework nucleic acids (tFNAs-miR22) nanostructure and evaluated its efficacy in CNV suppression. The nanocomplex was structurally validated, exhibiting high assembly fidelity and superior intraocular stability compared to serum conditions. In a laser-induced CNV mouse model, a single intravitreal injection of tFNAs-miR22 significantly redu","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T05:27:41.385Z","creation":"2026-05-26T03:12:05.497Z"},"accession":"S-EPMC12719782","cross_references":{"pubmed":["41438708"],"doi":["10.1016/j.mtbio.2025.102578"]}}