biostudies-literatureFranco-O'Byrne DNIA NIH HHS121308https://www.ebi.ac.uk/biostudies/studies/S-EPMC12720182biostudies-literatureUnknown316Aging affects brain structure and function alongside metabolic and vascular processes leading to energetic impairments. While local neurometabolic dysfunction in aging is well-documented, the influence of systemic cardiometabolic and vascular markers on brain structure and function remains less understood. We examine the link between cardiometabolic dysfunction (measured by an allostatic load index) and neurovascular burden (measured by white matter hyperintensities), and their associations with brain changes, including ventricular and hippocampal volume, as well as EEG activity, across the adult lifesplan. Analyzing data from 196 healthy individuals across ages (20-75 years), we found a significant positive correlation between allostatic load index and white-matter hyperintensities, irresNeuroImageCardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI.PMC12720182R01 AG057234Ibanez AMedel VTagliazucchi ECastro-Laguardia AMFranco-O'Byrne DShine JMHuepe DGonzalez-Gomez RDelgado CGonzalez-Campo CfalseCardiometabolic state links neurovascular burden with brain structure and function: Evidence from EEG and MRI.Aging affects brain structure and function alongside metabolic and vascular processes leading to energetic impairments. While local neurometabolic dysfunction in aging is well-documented, the influence of systemic cardiometabolic and vascular markers on brain structure and function remains less understood. We examine the link between cardiometabolic dysfunction (measured by an allostatic load index) and neurovascular burden (measured by white matter hyperintensities), and their associations with brain changes, including ventricular and hippocampal volume, as well as EEG activity, across the adult lifesplan. Analyzing data from 196 healthy individuals across ages (20-75 years), we found a significant positive correlation between allostatic load index and white-matter hyperintensities, irres2025-01-01T00:00:00Z2025 Aug2026-06-06T04:57:12.43Z2026-05-26T03:12:04.028ZS-EPMC127201824048040310.1016/j.neuroimage.2025.121308