{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["61"],"submitter":["Goto J"],"pubmed_abstract":["<h4>Background</h4>The oxidation of low-density lipoprotein cholesterol (LDL-C) plays a critical role in plaque inflammation and the subsequent high-risk plaque formation. However, the relationship between LDL-C oxidation and plaque morphology in patients with diabetes mellitus (DM) has not been systematically studied. The study aimed to investigate the association between LDL-C oxidation and plaque morphology assessed using optical coherence tomography (OCT).<h4>Methods</h4>A total of 138 patients with chronic coronary syndrome who underwent OCT were analyzed. Malondialdehyde-modified LDL-C (MDA-LDL), a representative form of oxidized LDL-C, was measured. Levels of LDL-C oxidation were assessed using the ratio of MDA-LDL to LDL-C ratio. Plaque morphology was assessed by OCT at the target "],"journal":["American heart journal plus : cardiology research and practice"],"pagination":["100691"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12723116"],"repository":["biostudies-literature"],"pubmed_title":["Oxidized low-density lipoprotein cholesterol and plaque vulnerability."],"pmcid":["PMC12723116"],"pubmed_authors":["Jang IK","Watanabe T","Otaki Y","Ra S","Ono H","Goto J","Mito T","Watanabe M","Kinoshita D","Shikama T","Kato S","Tachibana S"],"additional_accession":[]},"is_claimable":false,"name":"Oxidized low-density lipoprotein cholesterol and plaque vulnerability.","description":"<h4>Background</h4>The oxidation of low-density lipoprotein cholesterol (LDL-C) plays a critical role in plaque inflammation and the subsequent high-risk plaque formation. However, the relationship between LDL-C oxidation and plaque morphology in patients with diabetes mellitus (DM) has not been systematically studied. The study aimed to investigate the association between LDL-C oxidation and plaque morphology assessed using optical coherence tomography (OCT).<h4>Methods</h4>A total of 138 patients with chronic coronary syndrome who underwent OCT were analyzed. Malondialdehyde-modified LDL-C (MDA-LDL), a representative form of oxidized LDL-C, was measured. Levels of LDL-C oxidation were assessed using the ratio of MDA-LDL to LDL-C ratio. Plaque morphology was assessed by OCT at the target ","dates":{"release":"2026-01-01T00:00:00Z","publication":"2026 Jan","modification":"2026-06-07T05:21:58.791Z","creation":"2026-06-07T03:06:03.938Z"},"accession":"S-EPMC12723116","cross_references":{"pubmed":["41446700"],"doi":["10.1016/j.ahjo.2025.100691"]}}