biostudies-literatureUnknown61Goto J<h4>Background</h4>The oxidation of low-density lipoprotein cholesterol (LDL-C) plays a critical role in plaque inflammation and the subsequent high-risk plaque formation. However, the relationship between LDL-C oxidation and plaque morphology in patients with diabetes mellitus (DM) has not been systematically studied. The study aimed to investigate the association between LDL-C oxidation and plaque morphology assessed using optical coherence tomography (OCT).<h4>Methods</h4>A total of 138 patients with chronic coronary syndrome who underwent OCT were analyzed. Malondialdehyde-modified LDL-C (MDA-LDL), a representative form of oxidized LDL-C, was measured. Levels of LDL-C oxidation were assessed using the ratio of MDA-LDL to LDL-C ratio. Plaque morphology was assessed by OCT at the target American heart journal plus : cardiology research and practice100691https://www.ebi.ac.uk/biostudies/studies/S-EPMC12723116biostudies-literatureOxidized low-density lipoprotein cholesterol and plaque vulnerability.PMC12723116Jang IKWatanabe TOtaki YRa SOno HGoto JMito TWatanabe MKinoshita DShikama TKato STachibana SfalseOxidized low-density lipoprotein cholesterol and plaque vulnerability.<h4>Background</h4>The oxidation of low-density lipoprotein cholesterol (LDL-C) plays a critical role in plaque inflammation and the subsequent high-risk plaque formation. However, the relationship between LDL-C oxidation and plaque morphology in patients with diabetes mellitus (DM) has not been systematically studied. The study aimed to investigate the association between LDL-C oxidation and plaque morphology assessed using optical coherence tomography (OCT).<h4>Methods</h4>A total of 138 patients with chronic coronary syndrome who underwent OCT were analyzed. Malondialdehyde-modified LDL-C (MDA-LDL), a representative form of oxidized LDL-C, was measured. Levels of LDL-C oxidation were assessed using the ratio of MDA-LDL to LDL-C ratio. Plaque morphology was assessed by OCT at the target 2026-01-01T00:00:00Z2026 Jan2026-06-07T05:21:58.791Z2026-06-07T03:06:03.938ZS-EPMC127231164144670010.1016/j.ahjo.2025.100691