{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Hoffman K"],"funding":["NCI NIH HHS"],"pubmed_abstract":["<h4>Background</h4>Primary malignant brain tumors (PMBTs), including glioblastomas (GBM) and low-grade gliomas (LGGs), frequently cause seizures, which worsen patient morbidity and quality of life. Alcohol use disorder (AUD) is a known risk factor for seizures in the general population, but its role in PMBT-associated seizures remains poorly understood.<h4>Objective</h4>To evaluate the association between AUD and seizure prevalence in PMBT patients, and to examine whether this relationship varies by age, sex, race/ethnicity, and tumor grade.<h4>Methods</h4>We conducted a retrospective cohort study using the Cosmos EHR database (2015-2025), identifying 244,955 adult patients with PMBTs. Seizure/epilepsy and AUD diagnoses were ascertained via ICD-10 codes. Associations were assessed using ch"],"journal":["medRxiv : the preprint server for health sciences"],"pagination":["2025.12.11.25342079"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12723976"],"repository":["biostudies-literature"],"pubmed_title":["Alcohol use disorder and epileptogenesis in primary malignant brain tumors: temporal and tumor grade associations in a nationwide EHR cohort study."],"pmcid":["PMC12723976"],"funding_grant_id":["R01 CA263628"],"pubmed_authors":["Shah M","Hoffman K","Akinpelu D","Madsen J","Meyer J"],"additional_accession":[]},"is_claimable":false,"name":"Alcohol use disorder and epileptogenesis in primary malignant brain tumors: temporal and tumor grade associations in a nationwide EHR cohort study.","description":"<h4>Background</h4>Primary malignant brain tumors (PMBTs), including glioblastomas (GBM) and low-grade gliomas (LGGs), frequently cause seizures, which worsen patient morbidity and quality of life. Alcohol use disorder (AUD) is a known risk factor for seizures in the general population, but its role in PMBT-associated seizures remains poorly understood.<h4>Objective</h4>To evaluate the association between AUD and seizure prevalence in PMBT patients, and to examine whether this relationship varies by age, sex, race/ethnicity, and tumor grade.<h4>Methods</h4>We conducted a retrospective cohort study using the Cosmos EHR database (2015-2025), identifying 244,955 adult patients with PMBTs. Seizure/epilepsy and AUD diagnoses were ascertained via ICD-10 codes. Associations were assessed using ch","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-04T03:21:20.836Z","creation":"2026-06-04T03:12:46.028Z"},"accession":"S-EPMC12723976","cross_references":{"pubmed":["41445607"],"doi":["10.64898/2025.12.11.25342079"]}}