biostudies-literatureUnknownHoffman KNCI NIH HHS<h4>Background</h4>Primary malignant brain tumors (PMBTs), including glioblastomas (GBM) and low-grade gliomas (LGGs), frequently cause seizures, which worsen patient morbidity and quality of life. Alcohol use disorder (AUD) is a known risk factor for seizures in the general population, but its role in PMBT-associated seizures remains poorly understood.<h4>Objective</h4>To evaluate the association between AUD and seizure prevalence in PMBT patients, and to examine whether this relationship varies by age, sex, race/ethnicity, and tumor grade.<h4>Methods</h4>We conducted a retrospective cohort study using the Cosmos EHR database (2015-2025), identifying 244,955 adult patients with PMBTs. Seizure/epilepsy and AUD diagnoses were ascertained via ICD-10 codes. Associations were assessed using chmedRxiv : the preprint server for health sciences2025.12.11.25342079https://www.ebi.ac.uk/biostudies/studies/S-EPMC12723976biostudies-literatureAlcohol use disorder and epileptogenesis in primary malignant brain tumors: temporal and tumor grade associations in a nationwide EHR cohort study.PMC12723976R01 CA263628Shah MHoffman KAkinpelu DMadsen JMeyer JfalseAlcohol use disorder and epileptogenesis in primary malignant brain tumors: temporal and tumor grade associations in a nationwide EHR cohort study.<h4>Background</h4>Primary malignant brain tumors (PMBTs), including glioblastomas (GBM) and low-grade gliomas (LGGs), frequently cause seizures, which worsen patient morbidity and quality of life. Alcohol use disorder (AUD) is a known risk factor for seizures in the general population, but its role in PMBT-associated seizures remains poorly understood.<h4>Objective</h4>To evaluate the association between AUD and seizure prevalence in PMBT patients, and to examine whether this relationship varies by age, sex, race/ethnicity, and tumor grade.<h4>Methods</h4>We conducted a retrospective cohort study using the Cosmos EHR database (2015-2025), identifying 244,955 adult patients with PMBTs. Seizure/epilepsy and AUD diagnoses were ascertained via ICD-10 codes. Associations were assessed using ch2025-01-01T00:00:00Z2025 Dec2026-06-04T03:21:20.836Z2026-06-04T03:12:46.028ZS-EPMC127239764144560710.64898/2025.12.11.25342079