{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["99(12)"],"submitter":["Arbuckle JH"],"funding":["National Institute of Allergy and Infectious Diseases"],"pubmed_abstract":["Epigenetic modulation of herpes simplex virus (HSV) immediate early (IE) genes is a critical parameter governing lytic infection, latency, and viral reactivation. Multiple factors, including epigenetic complexes associated with the cellular transcriptional coactivator HCF-1, modulate the state of HSV-1 chromatin. Although some aspects of HSV-1 chromatin biology have been elucidated, many epigenetic factors controlling HSV-1 chromatin accessibility and transcriptional regulation remain unknown. To identify novel epigenetic regulators of the initial stage of HSV-1 infection, an epigenetic chemical probe library was screened for molecules that impacted viral IE gene expression. This screen identified several epigenetic inhibitors that modulated IE expression. Notably, UNC0379, an inhibitor of"],"journal":["Journal of virology"],"pagination":["e0129325"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12724366"],"repository":["biostudies-literature"],"pubmed_title":["The H4K20-mono-methyltransferase SETD8 promotes global accessibility of infecting herpes simplex virus genomes."],"pmcid":["PMC12724366"],"pubmed_authors":["Vogel JL","McBride AA","Markowitz TE","Yanez AA","Kristie TM","Arbuckle JH","Baksh SS"],"additional_accession":[]},"is_claimable":false,"name":"The H4K20-mono-methyltransferase SETD8 promotes global accessibility of infecting herpes simplex virus genomes.","description":"Epigenetic modulation of herpes simplex virus (HSV) immediate early (IE) genes is a critical parameter governing lytic infection, latency, and viral reactivation. Multiple factors, including epigenetic complexes associated with the cellular transcriptional coactivator HCF-1, modulate the state of HSV-1 chromatin. Although some aspects of HSV-1 chromatin biology have been elucidated, many epigenetic factors controlling HSV-1 chromatin accessibility and transcriptional regulation remain unknown. To identify novel epigenetic regulators of the initial stage of HSV-1 infection, an epigenetic chemical probe library was screened for molecules that impacted viral IE gene expression. This screen identified several epigenetic inhibitors that modulated IE expression. Notably, UNC0379, an inhibitor of","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-08T05:17:31.065Z","creation":"2026-06-08T03:09:01.277Z"},"accession":"S-EPMC12724366","cross_references":{"pubmed":["41258712"],"doi":["10.1128/jvi.01293-25"]}}