{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dias ALB"],"funding":["Conselho Nacional de Desenvolvimento Científico e Tecnológico","Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","Fundação de Amparo à Pesquisa do Estado do Amazonas"],"pagination":["e0331729"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12725547"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(12)"],"pubmed_abstract":["<h4>Background</h4>Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is a common genetic disorder that impairs the cellular antioxidant response and has been hypothesized as a potential risk factor for severe outcomes in viral infections, including COVID-19. However, clinical evidence remains limited, especially in regions with high G6PDd prevalence.<h4>Methods</h4>We conducted a retrospective cohort study using secondary data from four health information systems from health facilities in the Brazilian Amazon (E-SUS Notifica, SIVEP-Gripe, SIM, and a G6PD enzyme activity database). The study population consisted of 3,955 male participants, including 206 with confirmed G6PDd. We used logistic regression to assess associations between G6PDd and COVID-19 infection, hospitalization, and deat"],"journal":["PloS one"],"pubmed_title":["Is glucose-6-phosphate dehydrogenase deficiency associated with COVID-19 infection, severity, and death? A cohort study from the Brazilian Amazon."],"pmcid":["PMC12725547"],"funding_grant_id":["Edital nº 09/2020","PQ","Posgrad 2024/2025"],"pubmed_authors":["da Silva KF","Dias ALB","Nascimento JR","Brito-Sousa JD","Monteiro W","de Melo GC","Silva-Neto AV","Sartim MA","Baia-da-Silva DC","Almeida-Val F","da Silva Balieiro PC","Dos Santos Mouta G","Sampaio VS","Lacerda M"],"additional_accession":[]},"is_claimable":false,"name":"Is glucose-6-phosphate dehydrogenase deficiency associated with COVID-19 infection, severity, and death? A cohort study from the Brazilian Amazon.","description":"<h4>Background</h4>Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is a common genetic disorder that impairs the cellular antioxidant response and has been hypothesized as a potential risk factor for severe outcomes in viral infections, including COVID-19. However, clinical evidence remains limited, especially in regions with high G6PDd prevalence.<h4>Methods</h4>We conducted a retrospective cohort study using secondary data from four health information systems from health facilities in the Brazilian Amazon (E-SUS Notifica, SIVEP-Gripe, SIM, and a G6PD enzyme activity database). The study population consisted of 3,955 male participants, including 206 with confirmed G6PDd. We used logistic regression to assess associations between G6PDd and COVID-19 infection, hospitalization, and deat","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025","modification":"2026-06-08T05:04:40.881Z","creation":"2026-06-08T03:08:53.266Z"},"accession":"S-EPMC12725547","cross_references":{"pubmed":["41433239"],"doi":["10.1371/journal.pone.0331729"]}}