biostudies-literatureDias ALBConselho Nacional de Desenvolvimento Científico e TecnológicoCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFundação de Amparo à Pesquisa do Estado do Amazonase0331729https://www.ebi.ac.uk/biostudies/studies/S-EPMC12725547biostudies-literatureUnknown20(12)<h4>Background</h4>Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is a common genetic disorder that impairs the cellular antioxidant response and has been hypothesized as a potential risk factor for severe outcomes in viral infections, including COVID-19. However, clinical evidence remains limited, especially in regions with high G6PDd prevalence.<h4>Methods</h4>We conducted a retrospective cohort study using secondary data from four health information systems from health facilities in the Brazilian Amazon (E-SUS Notifica, SIVEP-Gripe, SIM, and a G6PD enzyme activity database). The study population consisted of 3,955 male participants, including 206 with confirmed G6PDd. We used logistic regression to assess associations between G6PDd and COVID-19 infection, hospitalization, and deatPloS oneIs glucose-6-phosphate dehydrogenase deficiency associated with COVID-19 infection, severity, and death? A cohort study from the Brazilian Amazon.PMC12725547Edital nº 09/2020PQPosgrad 2024/2025da Silva KFDias ALBNascimento JRBrito-Sousa JDMonteiro Wde Melo GCSilva-Neto AVSartim MABaia-da-Silva DCAlmeida-Val Fda Silva Balieiro PCDos Santos Mouta GSampaio VSLacerda MfalseIs glucose-6-phosphate dehydrogenase deficiency associated with COVID-19 infection, severity, and death? A cohort study from the Brazilian Amazon.<h4>Background</h4>Glucose-6-phosphate dehydrogenase deficiency (G6PDd) is a common genetic disorder that impairs the cellular antioxidant response and has been hypothesized as a potential risk factor for severe outcomes in viral infections, including COVID-19. However, clinical evidence remains limited, especially in regions with high G6PDd prevalence.<h4>Methods</h4>We conducted a retrospective cohort study using secondary data from four health information systems from health facilities in the Brazilian Amazon (E-SUS Notifica, SIVEP-Gripe, SIM, and a G6PD enzyme activity database). The study population consisted of 3,955 male participants, including 206 with confirmed G6PDd. We used logistic regression to assess associations between G6PDd and COVID-19 infection, hospitalization, and deat2025-01-01T00:00:00Z20252026-06-08T05:04:40.881Z2026-06-08T03:08:53.266ZS-EPMC127255474143323910.1371/journal.pone.0331729