{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rippa A"],"funding":["NIDDK NIH HHS","NIAID NIH HHS","Foundation for the National Institutes of Health","Foundation for the National Institutes of Health (Foundation for the National Institutes of Health, Inc.)"],"pagination":["11379"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12727770"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["A high-definition description of pancreatic islets would prove beneficial for understanding the pathophysiology of type 1 diabetes (T1D), yet significant knowledge gaps exist in terms of their size, endocrine cell composition, and number in both health and disease. Here, 3-dimensional (3D) analyses of pancreata from control persons without diabetes (ND) demonstrate approximately 50% of islets are insulin-positive (INS + ) glucagon-negative (GCG-). Non-diabetic individuals positive for a single Glutamic acid decarboxylase autoantibody (GADA + ) yet at increased risk for disease consistently demonstrate endocrine features, including islet volume and cell composition, closely resembling the age-matched ND controls. In contrast, pancreata from individuals with short-duration T1D demonstrate significantly reduced islet density and a dramatic loss of INS + GCG- islets with preservation of large INS + GCG+ islets. The size and cellular composition of pancreatic islets may, therefore, represent influential factors that impact β-cell loss during T1D disease progression."],"journal":["Nature communications"],"pubmed_title":["3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes."],"pmcid":["PMC12727770"],"funding_grant_id":["R01 DK131059","R01 DK123292","U24 DK104162","R01DK131059","P01 AI042288","P01AI042288","R01DK123292","U01 DK135001"],"pubmed_authors":["Rippa A","Currlin S","Kaddis JS","Williams MD","Wasserfall CH","Atkinson MA","Kusmartseva I","Posgai AL","Brusko M","Campbell-Thompson M"],"additional_accession":[]},"is_claimable":false,"name":"3D imaging of human pancreas suggests islet size and endocrine composition influence their loss in type 1 diabetes.","description":"A high-definition description of pancreatic islets would prove beneficial for understanding the pathophysiology of type 1 diabetes (T1D), yet significant knowledge gaps exist in terms of their size, endocrine cell composition, and number in both health and disease. Here, 3-dimensional (3D) analyses of pancreata from control persons without diabetes (ND) demonstrate approximately 50% of islets are insulin-positive (INS + ) glucagon-negative (GCG-). Non-diabetic individuals positive for a single Glutamic acid decarboxylase autoantibody (GADA + ) yet at increased risk for disease consistently demonstrate endocrine features, including islet volume and cell composition, closely resembling the age-matched ND controls. In contrast, pancreata from individuals with short-duration T1D demonstrate significantly reduced islet density and a dramatic loss of INS + GCG- islets with preservation of large INS + GCG+ islets. The size and cellular composition of pancreatic islets may, therefore, represent influential factors that impact β-cell loss during T1D disease progression.","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-06T05:15:59.129Z","creation":"2026-05-26T03:12:07.956Z"},"accession":"S-EPMC12727770","cross_references":{"pubmed":["41381473"],"doi":["10.1038/s41467-025-66198-6"]}}