{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Colombo RE"],"funding":["Defense Health Program","National Institutes of Health","Department of Defense","Inter-Agency","National Institute of Allergy and Infectious Diseases","Defense Health Agency Immunization Healthcare Division","Infectious Disease Clinical Research Program","National Cancer Institute","NCI NIH HHS","US Department of Defense","National Institutes of Health Clinical Center","NIH HHS","Uniformed Services University of the Health Sciences"],"pagination":["e454-e463"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12728286"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["81(5)"],"pubmed_abstract":["<h4>Background</h4>Influenza is a major cause of morbidity and mortality worldwide. The Pragmatic Assessment of Influenza Vaccine Effectiveness (VE) in the Department of Defense (PAIVED) study compared the relative VE (rVE) of 2 licensed influenza vaccines (cell culture-based inactivated influenza vaccine [ccIIV] and recombinant influenza vaccine [RIV]) to egg-based inactivated influenza vaccine (eIIV).<h4>Methods</h4>Between 2018 and 2021, PAIVED randomized (1:1:1) eligible Military Health System beneficiaries to receive eIIV, ccIIV, or RIV during an influenza season. Participants received weekly surveys querying influenza-like illness (ILI); those reporting ILI completed an online symptom diary, were interviewed by research staff, and underwent nasal swab collection. Laboratory-confirmed"],"journal":["Clinical infectious diseases : an official publication of the Infectious Diseases Society of America"],"pubmed_title":["Randomized Pragmatic Trial of the Comparative Effectiveness of Chicken Egg-Based Inactivated, Mammalian Cell Culture-Based Inactivated, and Recombinant Protein Quadrivalent Seasonal Influenza Vaccines in United States Military Health System Beneficiaries."],"pmcid":["PMC12728286"],"funding_grant_id":["HU0001190002","75N91019D00024","75N91019F00130","Y1-Al-5072"],"pubmed_authors":["Jefferson J","Cerroni M","Williams A","Austin A","Burgess T","Armstrong C","Lalani T","Bowers R","Richard SA","Modi JR","Martin M","Warkentien T","Richard S","Becher D","Richardson M","Colombo RE","Matthews K","Banks S","O'Connell RJ","Pollett S","Spooner C","Sundaram AK","Colombo R","Grance M","Loo S","Hogan V","Jones B","Turner D","Parmelee E","Lawson L","Lohsl C","Nall D","Zollicoffer G","Hall E","Nivens A","Bazan S","Parish D","Farmer A","Tant R","Ganesan A","Friend C","Coles CL","Clakley B","Simons MP","Olsen C","Coles C","Moreno N","PAIVED Study Group","Modi J","Bowman J","Simon J","Baker C","Kosh L","Ortega O","Loy S","Schmidt K","Berjohn CM","Zell ER","Crosby D","Tilley D","Saperstein A","Hussain M","Park H","Dunham J","Heilweil M","Berjohn C","Cochran A","McNiff J","Rothenberg J","McClenathan B","Tilley DH","Kirkland N","Fries A","Fritschlanski M","Ritschl J","Purves S","Housel L","Gyben K","Maves R","Barahona I","Markelz AE","Burgess TH","Hrncir D","Merritt T","Merritt S","Powers J","Schofield C","Murillo C","Campbell W","Romero M","Utz G","Smith A","Marrier C","McClung A","Ewing D","King A","Gazlay L","Seshadri S","Blankenship K","Wayman M","Mende K","Powers Iii JH","Swarthout-Ebarb A","Simons M","Brunader J","Chambers S","Smith R","Maves RC","Collins G","Pollett SD","Bedno S","Collins L","Macisaac M","Larson D"],"additional_accession":[]},"is_claimable":false,"name":"Randomized Pragmatic Trial of the Comparative Effectiveness of Chicken Egg-Based Inactivated, Mammalian Cell Culture-Based Inactivated, and Recombinant Protein Quadrivalent Seasonal Influenza Vaccines in United States Military Health System Beneficiaries.","description":"<h4>Background</h4>Influenza is a major cause of morbidity and mortality worldwide. The Pragmatic Assessment of Influenza Vaccine Effectiveness (VE) in the Department of Defense (PAIVED) study compared the relative VE (rVE) of 2 licensed influenza vaccines (cell culture-based inactivated influenza vaccine [ccIIV] and recombinant influenza vaccine [RIV]) to egg-based inactivated influenza vaccine (eIIV).<h4>Methods</h4>Between 2018 and 2021, PAIVED randomized (1:1:1) eligible Military Health System beneficiaries to receive eIIV, ccIIV, or RIV during an influenza season. Participants received weekly surveys querying influenza-like illness (ILI); those reporting ILI completed an online symptom diary, were interviewed by research staff, and underwent nasal swab collection. Laboratory-confirmed","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-09T04:54:18.152Z","creation":"2026-06-09T03:07:36.502Z"},"accession":"S-EPMC12728286","cross_references":{"pubmed":["40973113"],"doi":["10.1093/cid/ciaf503"]}}