biostudies-literatureJiang XZhejiang Provincial Medical and Health Project"Pioneer" and "Leading Goose" R&D Program of ZhejiangNational Key Research and Development Program of China1035https://www.ebi.ac.uk/biostudies/studies/S-EPMC12729072biostudies-literatureUnknown25(1)<h4>Background</h4>Tuberculosis (TB) latent infection is a crucial precursor to the development of active pulmonary tuberculosis while currently no gold standard for detecting latent infection. This study aims to investigate the prevalence of latent infection among the elderly in high-incidence areas in Eastern China. Additionally, it compares the agreement of two interferon-γ release assay (IGRA) reagents in detecting latent TB infection in this elderly population.<h4>Methods</h4>A random sampling method was adopted to select two townships from Lanxi City, China. Based on the health check-ups for the elderly under the National Basic Public Health Service Project, a questionnaire survey and latent infection testing were conducted among the recruited elderly population aged 65 and above. A BMC geriatricsThe latent tuberculosis infection survey using two interferon γ release assay tests among the elderly in a well-confined rural county in Eastern China.PMC12729072No.2025C01134Grant No.2024YFC23112022025KY774Jiang JChen QLiu KZhu YJiang GFeng YZhang MChen BTong WJiang XWang WHu LYu ZfalseThe latent tuberculosis infection survey using two interferon γ release assay tests among the elderly in a well-confined rural county in Eastern China.<h4>Background</h4>Tuberculosis (TB) latent infection is a crucial precursor to the development of active pulmonary tuberculosis while currently no gold standard for detecting latent infection. This study aims to investigate the prevalence of latent infection among the elderly in high-incidence areas in Eastern China. Additionally, it compares the agreement of two interferon-γ release assay (IGRA) reagents in detecting latent TB infection in this elderly population.<h4>Methods</h4>A random sampling method was adopted to select two townships from Lanxi City, China. Based on the health check-ups for the elderly under the National Basic Public Health Service Project, a questionnaire survey and latent infection testing were conducted among the recruited elderly population aged 65 and above. A 2025-01-01T00:00:00Z2025 Dec2026-06-06T05:41:48.234Z2026-05-26T03:12:18.935ZS-EPMC127290724144493910.1186/s12877-025-06739-2