{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gulum L"],"funding":["Bolu Abant İzzet Baysal University"],"pagination":["1471"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12730045"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(12)"],"pubmed_abstract":["<i>Ganoderma lucidum</i> has long been recognized for its medicinal properties, particularly due to its antioxidant, anti-inflammatory, and pro-apoptotic components such as polysaccharides and triterpenoids. This study aimed to evaluate the cytotoxic and molecular effects of ethanol and methanol extracts of <i>G. lucidum</i> as well as doxorubicin on MCF-7 breast cancer cells. The cytotoxicity was assessed via MTT assay. The methanol extract showed stronger cytotoxicity (IC<sub>50</sub>: 62.37 µg/mL) than the ethanol extract, while doxorubicin exhibited an IC<sub>50</sub> value of 0.66 mM. Phenolic profiling by HPLC revealed high levels of vanillic acid, gallic acid and (-)-epicatechin in the methanol extract, while volatile compounds such as hexanal and acetic acid were identified by GC-M"],"journal":["Antioxidants (Basel, Switzerland)"],"pubmed_title":["Evaluation of Anticancer Potential of &lt;i&gt;Ganoderma lucidum&lt;/i&gt; on MCF-7 Breast Cancer Cells Through Genetic Transcription of Energy Metabolism."],"pmcid":["PMC12730045"],"funding_grant_id":["2024-BDP-6.10.41-0008"],"pubmed_authors":["Guler E","Capkınoglu E","Gulum L","Celik AB","Tutar Y"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of Anticancer Potential of &lt;i&gt;Ganoderma lucidum&lt;/i&gt; on MCF-7 Breast Cancer Cells Through Genetic Transcription of Energy Metabolism.","description":"<i>Ganoderma lucidum</i> has long been recognized for its medicinal properties, particularly due to its antioxidant, anti-inflammatory, and pro-apoptotic components such as polysaccharides and triterpenoids. This study aimed to evaluate the cytotoxic and molecular effects of ethanol and methanol extracts of <i>G. lucidum</i> as well as doxorubicin on MCF-7 breast cancer cells. The cytotoxicity was assessed via MTT assay. The methanol extract showed stronger cytotoxicity (IC<sub>50</sub>: 62.37 µg/mL) than the ethanol extract, while doxorubicin exhibited an IC<sub>50</sub> value of 0.66 mM. Phenolic profiling by HPLC revealed high levels of vanillic acid, gallic acid and (-)-epicatechin in the methanol extract, while volatile compounds such as hexanal and acetic acid were identified by GC-M","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-05-28T03:15:06.313Z","creation":"2026-05-28T03:08:01.877Z"},"accession":"S-EPMC12730045","cross_references":{"pubmed":["41462671"],"doi":["10.3390/antiox14121471"]}}