{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Reinsberg A"],"funding":["Estonian Research Council"],"pagination":["1286"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12730293"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(12)"],"pubmed_abstract":["<b>Objective</b>: Neuronal growth regulator 1 (<i>Negr1</i>) is a GPI-anchored neuronal cell adhesion molecule of the IgLON superfamily associated with multiple psychiatric disorders. This study aimed to investigate behavioral and molecular adaptations to social isolation (SI) stress in <i>Negr1</i>-deficient (<i>Negr1<sup>-/-</sup></i>) mice. <b>Methods</b>: Male and female <i>Negr1<sup>-/-</sup></i> and wild-type (Wt) mice (n = 10 per group) were exposed to two weeks of SI or group housing (Ctl). Behavioral assays assessed exploratory and anxiety-like behavior. Gene expression analyses in the prefrontal cortex and hippocampus were performed using RT-qPCR, focusing on GABAergic, neurotrophic, and IgLON family genes. <b>Results</b>: SI-induced weight loss in <i>Negr1<sup>-/-</sup></i> mice"],"journal":["Brain sciences"],"pubmed_title":["Negr1 Deficiency Modulates Sex-Specific Neurobehavioral Adaptations to Social Isolation."],"pmcid":["PMC12730293"],"funding_grant_id":["PRG2544 and TARISTU24-TK22"],"pubmed_authors":["Singh K","Jayaram M","Philips MA","Reinsberg A","Vasar E","Mikheim K"],"additional_accession":[]},"is_claimable":false,"name":"Negr1 Deficiency Modulates Sex-Specific Neurobehavioral Adaptations to Social Isolation.","description":"<b>Objective</b>: Neuronal growth regulator 1 (<i>Negr1</i>) is a GPI-anchored neuronal cell adhesion molecule of the IgLON superfamily associated with multiple psychiatric disorders. This study aimed to investigate behavioral and molecular adaptations to social isolation (SI) stress in <i>Negr1</i>-deficient (<i>Negr1<sup>-/-</sup></i>) mice. <b>Methods</b>: Male and female <i>Negr1<sup>-/-</sup></i> and wild-type (Wt) mice (n = 10 per group) were exposed to two weeks of SI or group housing (Ctl). Behavioral assays assessed exploratory and anxiety-like behavior. Gene expression analyses in the prefrontal cortex and hippocampus were performed using RT-qPCR, focusing on GABAergic, neurotrophic, and IgLON family genes. <b>Results</b>: SI-induced weight loss in <i>Negr1<sup>-/-</sup></i> mice","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-26T20:07:40.415Z","creation":"2026-05-26T03:12:06.483Z"},"accession":"S-EPMC12730293","cross_references":{"pubmed":["41440084"],"doi":["10.3390/brainsci15121286"]}}