biostudies-literatureUnknown13(12)Ruiz-Saez H<b>Background:</b> Headache is a common symptom during acute viral infections, and its pathophysiology has been linked with the immune response to the virus. Headache is one of the most frequent symptoms of coronavirus disease 2019 (COVID-19), and it has been associated with a more efficient immune response and a better prognosis. The aim of this article is to evaluate whether vaccination could modify the clinical phenotype and the probability of developing persistent headache after acute COVID-19. <b>Methods:</b> A case-control study comparing the duration of the headache and the clinical phenotype between fully vaccinated individuals and non-vaccinated controls was conducted. Each case was matched with two controls that were paired by age, sex, and prior history of headache. Patients werBiomedicines2900https://www.ebi.ac.uk/biostudies/studies/S-EPMC12731189biostudies-literatureCOVID-19 Vaccination Modifies COVID-19-Related Headache Phenotype: Evidence from Case-Control Study on 309 Participants.PMC12731189Blanco MMartinez Badillo CRecio-Garcia AHurtado MLSierra-Mencia APlanchuelo-Gomez ANunez GEchavarria Iniguez ACornejo ARuiz MGarcia-Azorin DPaniagua MGil ARojas-Hernandez MCubero MAlberdi-Iglesias AGonzalez-Celestino APerez Almendro CMora MLozano AGFernandez-de-Las-Penas CMontilla CRuiz-Saez HGarcia-Iglesias CGonzalez Osorio YCalcerrada IGuerrero Peral ALSierra LTrigo Lopez JfalseCOVID-19 Vaccination Modifies COVID-19-Related Headache Phenotype: Evidence from Case-Control Study on 309 Participants.<b>Background:</b> Headache is a common symptom during acute viral infections, and its pathophysiology has been linked with the immune response to the virus. Headache is one of the most frequent symptoms of coronavirus disease 2019 (COVID-19), and it has been associated with a more efficient immune response and a better prognosis. The aim of this article is to evaluate whether vaccination could modify the clinical phenotype and the probability of developing persistent headache after acute COVID-19. <b>Methods:</b> A case-control study comparing the duration of the headache and the clinical phenotype between fully vaccinated individuals and non-vaccinated controls was conducted. Each case was matched with two controls that were paired by age, sex, and prior history of headache. Patients wer2025-01-01T00:00:00Z2025 Nov2026-05-28T03:15:16.428Z2026-05-28T03:08:02.643ZS-EPMC127311894146291210.3390/biomedicines13122900