{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["32(12)"],"submitter":["Lauk O"],"pubmed_abstract":["<b>Background:</b> Myasthenia gravis (MG) is frequently associated with thymic abnormalities, including thymomas and hyperplasia. This study aims to analyze the clinical and pathological characteristics of thymectomized patients over a 20-year period, focusing on the relationship between thymoma subtype and MG incidence, as well as post-thymectomy remission outcomes. <b>Methods:</b> We retrospectively analyzed 420 patients who underwent thymectomy (open or VATS), with a mean age of 54.4 years and 59% female. Thymic pathology included thymomas (56.2%), thymic cysts (14.3%), and other lesions. 39.5% of patients had MG, of which 48.8% were thymomatous MG. Multivariate regression was used to identify predictors of MG and remission outcomes. <b>Results:</b> MG was significantly associated with "],"journal":["Current oncology (Toronto, Ont.)"],"pagination":["662"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12731372"],"repository":["biostudies-literature"],"pubmed_title":["Myasthenia Gravis and Thymectomy at a Tertiary-Care Surgical Centre: A 20-Year Retrospective Review."],"pmcid":["PMC12731372"],"pubmed_authors":["Sharma S","De Oliveira AS","Jack K","Yee J","Lauk O","Briemberg H","Mezei M","Huynh C","Chapman K","Vieira A","McGuire AL"],"additional_accession":[]},"is_claimable":false,"name":"Myasthenia Gravis and Thymectomy at a Tertiary-Care Surgical Centre: A 20-Year Retrospective Review.","description":"<b>Background:</b> Myasthenia gravis (MG) is frequently associated with thymic abnormalities, including thymomas and hyperplasia. This study aims to analyze the clinical and pathological characteristics of thymectomized patients over a 20-year period, focusing on the relationship between thymoma subtype and MG incidence, as well as post-thymectomy remission outcomes. <b>Methods:</b> We retrospectively analyzed 420 patients who underwent thymectomy (open or VATS), with a mean age of 54.4 years and 59% female. Thymic pathology included thymomas (56.2%), thymic cysts (14.3%), and other lesions. 39.5% of patients had MG, of which 48.8% were thymomatous MG. Multivariate regression was used to identify predictors of MG and remission outcomes. <b>Results:</b> MG was significantly associated with ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Nov","modification":"2026-05-26T17:07:40.882Z","creation":"2026-05-25T03:11:36.345Z"},"accession":"S-EPMC12731372","cross_references":{"pubmed":["41440190"],"doi":["10.3390/curroncol32120662"]}}