biostudies-literatureUnknown31(72)Heinrich SUniversity of CalgaryMitsubishi Chemical Center for Advanced MaterialsLithium is a critical element with a projected exponential rise in demand due to its widespread use in battery energy storage. New methods to extract Li⁺, such as through membrane adsorption-based direct Li⁺ extraction (DLE) technologies, are at various stages of development and aim to separate Li⁺ from brine and even seawater. In this report, we present a fundamentally new class of highly selective Li⁺-capture agent, the carborane-crown compound, 1,2-((6,6,7,7-Me₄)14-crown-4)-ortho-carborane (^14C4Cb), which is electrochemically activated for strong, selective Li⁺ binding over Na⁺ and K⁺. This newly synthesized extractant features a redox-tunable cavity size, giving rise to tunable binding coChemistry (Weinheim an der Bergstrasse, Germany)e02902https://www.ebi.ac.uk/biostudies/studies/S-EPMC12731541biostudies-literatureA Redox-Tunable Carborane Crown: Toward Highly Selective Electrochemical Lithium Capture.PMC12731541Sepunaru LMenard GYeow ADobrovetsky RRajpurohit JWang ZHeinrich SfalseA Redox-Tunable Carborane Crown: Toward Highly Selective Electrochemical Lithium Capture.Lithium is a critical element with a projected exponential rise in demand due to its widespread use in battery energy storage. New methods to extract Li⁺, such as through membrane adsorption-based direct Li⁺ extraction (DLE) technologies, are at various stages of development and aim to separate Li⁺ from brine and even seawater. In this report, we present a fundamentally new class of highly selective Li⁺-capture agent, the carborane-crown compound, 1,2-((6,6,7,7-Me₄)14-crown-4)-ortho-carborane (^14C4Cb), which is electrochemically activated for strong, selective Li⁺ binding over Na⁺ and K⁺. This newly synthesized extractant features a redox-tunable cavity size, giving rise to tunable binding co2025-01-01T00:00:00Z2025 Dec2026-06-06T04:30:31.757Z2026-05-25T03:11:37.89ZS-EPMC127315414124363810.1002/chem.202502902