{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(12)"],"submitter":["Wang Q"],"pubmed_abstract":["<b>Background/Objectives</b>: The PB family of \"cut-and-paste\" DNA transposons shows great promise as genetic manipulation tools while significantly impacting eukaryotic genome evolution. However, their evolutionary profile in beetles (Coleoptera), the most species-rich animal order, remains poorly characterized. <b>Methods</b>: A local tBLASTN search was conducted to mine PiggyBac (PB) transposons across 136 coleopteran insect genomes, using the DDE domain of the PB transposase as the query. Multiple sequence alignment was performed with MAFFT, and a maximum likelihood phylogenetic tree of the transposase DDE domains was constructed using IQ-TREE. Evolutionary dynamics were analyzed by means of K-divergence. <b>Results</b>: Our study reveals PB transposons are widely distributed, highly d"],"journal":["Genes"],"pagination":["1521"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12732532"],"repository":["biostudies-literature"],"pubmed_title":["Evolution Landscape of PiggyBac (PB) Transposon in Beetles (Coleoptera)."],"pmcid":["PMC12732532"],"pubmed_authors":["Gao B","Wang Q","Shi S","Wang B","Yang N","Song C","Chen X"],"additional_accession":[]},"is_claimable":false,"name":"Evolution Landscape of PiggyBac (PB) Transposon in Beetles (Coleoptera).","description":"<b>Background/Objectives</b>: The PB family of \"cut-and-paste\" DNA transposons shows great promise as genetic manipulation tools while significantly impacting eukaryotic genome evolution. However, their evolutionary profile in beetles (Coleoptera), the most species-rich animal order, remains poorly characterized. <b>Methods</b>: A local tBLASTN search was conducted to mine PiggyBac (PB) transposons across 136 coleopteran insect genomes, using the DDE domain of the PB transposase as the query. Multiple sequence alignment was performed with MAFFT, and a maximum likelihood phylogenetic tree of the transposase DDE domains was constructed using IQ-TREE. Evolutionary dynamics were analyzed by means of K-divergence. <b>Results</b>: Our study reveals PB transposons are widely distributed, highly d","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-05-27T03:15:43.506Z","creation":"2026-05-27T03:11:26.639Z"},"accession":"S-EPMC12732532","cross_references":{"pubmed":["41465194"],"doi":["10.3390/genes16121521"]}}