{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Rodriguez-Paez L"],"funding":["SECIHTI","Secretaría de Investigación y Posgrado del Instituto Politécnico Nacional"],"pagination":["11895"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12733172"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(24)"],"pubmed_abstract":["Autophagy is an intracellular process that recycles and degrades cytoplasmic components, including organelles and macromolecules, to provide energy and basic components for cell survival, maintain cellular homeostasis, and avoid self-damage. It is currently not fully known if mouse sperm undergoes the autophagy process, nor is the subcellular distribution, protein levels of autophagy-related proteins, and the biological role of autophagy in epididymal mouse sperm physiology fully understood. We aimed to investigate key autophagy markers, including LC3 (microtubule-associated protein 1A/1B-light chain 3), p62/SQSTM1 (Sequestosome 1), and mTOR (mechanistic Target of Rapamycin), in epididymal mouse sperm under capacitation (Cap) or non-capacitation (NC) conditions. Furthermore, we evaluated t"],"journal":["International journal of molecular sciences"],"pubmed_title":["Autophagy-Related Proteins Influence Mouse Epididymal Sperm Motility."],"pmcid":["PMC12733172"],"funding_grant_id":["95426","53185","6630","65406","20253438","11644"],"pubmed_authors":["Rodriguez-Paez L","Magana JJ","Cordero-Martinez J","Aguirre-Alvarado C","Chamorro-Cevallos G","Rosales-Cruz E","Cristobal-Luna JM","Jimenez-Gutierrez GE","Alcantara-Farfan V","Reyes-Maldonado E"],"additional_accession":[]},"is_claimable":false,"name":"Autophagy-Related Proteins Influence Mouse Epididymal Sperm Motility.","description":"Autophagy is an intracellular process that recycles and degrades cytoplasmic components, including organelles and macromolecules, to provide energy and basic components for cell survival, maintain cellular homeostasis, and avoid self-damage. It is currently not fully known if mouse sperm undergoes the autophagy process, nor is the subcellular distribution, protein levels of autophagy-related proteins, and the biological role of autophagy in epididymal mouse sperm physiology fully understood. We aimed to investigate key autophagy markers, including LC3 (microtubule-associated protein 1A/1B-light chain 3), p62/SQSTM1 (Sequestosome 1), and mTOR (mechanistic Target of Rapamycin), in epididymal mouse sperm under capacitation (Cap) or non-capacitation (NC) conditions. Furthermore, we evaluated t","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-06-04T03:20:27.699Z","creation":"2026-06-04T03:12:26.284Z"},"accession":"S-EPMC12733172","cross_references":{"pubmed":["41465325"],"doi":["10.3390/ijms262411895"]}}