{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Li ZZ"],"funding":["Key Project of Innovation Research 2035 Pilot Plan of Southwest University","National Natural Science Foundation of China","the Key Project of Tianjin Municipal Natural Science Foundation of China","Chongqing Graduate Research Innovation Project"],"pagination":["11836"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12733231"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(24)"],"pubmed_abstract":["The emergence of bacterial infections as a critical public health challenge underscores the urgent need for innovative therapeutic strategies. We designed and synthesized a series of novel heteroaryl bishydrozono nitroimidazoles and their analogs by strategically hybridizing multiple molecular components through diverse linkers. Among the newly synthesized compounds, compound <b>4</b> displayed a broad-spectrum antibacterial profile with low cytotoxicity and hemolysis. It could inhibit the proliferation of methicillin-resistant <i>Staphylococcus aureus</i> and reduce its metabolic activity with low bacterial resistance. Further investigations revealed that the highly active compound <b>4</b> could not only disrupt cell membrane integrity and induce excessive reactive oxygen species within "],"journal":["International journal of molecular sciences"],"pubmed_title":["Heteroaryl Bishydrazono Nitroimidazoles: A Unique Structural Skeleton with Potent Multitargeting Antibacterial Activity."],"pmcid":["PMC12733231"],"funding_grant_id":["24ZXZSSS00020","CYS18114","SWU-XDZD22007","82473771"],"pubmed_authors":["Liu YJ","Zhou CH","Li ZZ"],"additional_accession":[]},"is_claimable":false,"name":"Heteroaryl Bishydrazono Nitroimidazoles: A Unique Structural Skeleton with Potent Multitargeting Antibacterial Activity.","description":"The emergence of bacterial infections as a critical public health challenge underscores the urgent need for innovative therapeutic strategies. We designed and synthesized a series of novel heteroaryl bishydrozono nitroimidazoles and their analogs by strategically hybridizing multiple molecular components through diverse linkers. Among the newly synthesized compounds, compound <b>4</b> displayed a broad-spectrum antibacterial profile with low cytotoxicity and hemolysis. It could inhibit the proliferation of methicillin-resistant <i>Staphylococcus aureus</i> and reduce its metabolic activity with low bacterial resistance. Further investigations revealed that the highly active compound <b>4</b> could not only disrupt cell membrane integrity and induce excessive reactive oxygen species within ","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-05-28T03:18:37.598Z","creation":"2026-05-28T03:10:57.218Z"},"accession":"S-EPMC12733231","cross_references":{"pubmed":["41465266"],"doi":["10.3390/ijms262411836"]}}