{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Dotsenko VV"],"funding":["National Natural Science Foundation of China","Russian Science Foundation"],"pagination":["11874"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC12733256"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(24)"],"pubmed_abstract":["This work aimed to synthesize new derivatives of 2-hydrazinylpyridine-3-carbonitrile and to investigate their biological activity as safeners for the 2,4-D herbicide. The new 2-hydrazinylnicotinonitriles were obtained in high yields (up to quantitative) under mild conditions (25 °C, dioxane) by treating 4,6-diaryl-2-bromo-3-cyanopyridines with hydrazine hydrate. The latter were synthesized by brominating 2-(3-oxo-1,3-diarylpropyl)malononitriles, the Michael adducts, which are readily available from 1,3-diarylpropenones (chalcones) and malononitrile. An unusual side product of the bromination/carbocyclization was isolated and characterized; it consisted of co-crystals of 3-benzoyl-4-hydroxy-4-phenyl-2,6-di-(p-tolyl)cyclohexane-1,1-dicarbonitrile and 3-benzoyl-5-bromo-4-hydroxy-4-phenyl-2,6-"],"journal":["International journal of molecular sciences"],"pubmed_title":["Synthesis, Reactions, and Agrochemical Studies of New 4,6-Diaryl-2-hydrazinylnicotinonitriles."],"pmcid":["PMC12733256"],"funding_grant_id":["24-43-00003","22361132526"],"pubmed_authors":["Daus ES","Achmiz RG","Kindop VK","Dotsenko VV","Feng YQ","Temerdashev AZ","Zhu QF","Yudaev IV","Dakhno PG","Daus YV","Levchenko AG","Aksenov AV","Aksenov NA","Aksenova IV"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis, Reactions, and Agrochemical Studies of New 4,6-Diaryl-2-hydrazinylnicotinonitriles.","description":"This work aimed to synthesize new derivatives of 2-hydrazinylpyridine-3-carbonitrile and to investigate their biological activity as safeners for the 2,4-D herbicide. The new 2-hydrazinylnicotinonitriles were obtained in high yields (up to quantitative) under mild conditions (25 °C, dioxane) by treating 4,6-diaryl-2-bromo-3-cyanopyridines with hydrazine hydrate. The latter were synthesized by brominating 2-(3-oxo-1,3-diarylpropyl)malononitriles, the Michael adducts, which are readily available from 1,3-diarylpropenones (chalcones) and malononitrile. An unusual side product of the bromination/carbocyclization was isolated and characterized; it consisted of co-crystals of 3-benzoyl-4-hydroxy-4-phenyl-2,6-di-(p-tolyl)cyclohexane-1,1-dicarbonitrile and 3-benzoyl-5-bromo-4-hydroxy-4-phenyl-2,6-","dates":{"release":"2025-01-01T00:00:00Z","publication":"2025 Dec","modification":"2026-05-27T08:02:59.606Z","creation":"2026-05-27T03:12:25.183Z"},"accession":"S-EPMC12733256","cross_references":{"pubmed":["41465303"],"doi":["10.3390/ijms262411874"]}}